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首页> 外文期刊>Journal of cellular physiology. >Archetypal autophagic players through new lenses for bone marrow stem/mature cells regulation
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Archetypal autophagic players through new lenses for bone marrow stem/mature cells regulation

机译：典型的自噬玩家通过新的眼镜骨髓干细胞/成熟细胞监管

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摘要

The bone marrow landscape consists of specialized and stem/progenitor cells, which coordinate important tissue-related and systemic physiological features. Within the marrow cavity, stem/progenitor and differentiated hematopoietic and skeletal cells congregate into dynamic functional assemblies throughout specific anatomical regions, termed niches. There is a need for better understanding of the bone marrow microareas, through exploration of the intramural physical and molecular interactions of the distinctive cell populations. The elective liaisons established among the mesenchymal/stromal stem cell and hematopoietic stem cell lineage trees play a key role in orchestrating the stem/mature cell behavior and customized hierarchies within bone marrow cell populations. Recently, the autophagic apparatus has been discovered to be an important feature of bone marrow homeostasis. Autophagy-related factors involved in the labyrinthic and highly dynamic bone marrow workshop redesign the niche framework by coordinating the operational schedule of pluripotent stem and mature cells. The following report summarizes the most recent breakthroughs in our understanding of the intramural relationships between bone marrow cells and key autophagic mediators. Doubtless, the consideration of the autophagy-related and unrelated functions of main players, such as p62, Atg7, Atg5, and Beclin-1 remains a compelling task to thoroughly understand the complex relations between the heterogenic cell types that populate bone marrow.
机译：骨髓景观由专业协调和干细胞/祖细胞重要的约和系统性生理功能。造血干细胞/祖和分化和骨骼细胞聚集成动态的在特定的功能组件解剖区域,称为利基市场。需要更好地了解骨髓microareas,通过校内的探索生理和分子的相互作用独特的细胞群。联络人之间建立间充质/基质干细胞和造血干细胞谱系树过程中扮演着重要角色编排阀杆/成熟的细胞行为骨髓细胞内自定义层次结构人群。被发现的一个重要特性骨髓内稳态。错综复杂的和高度的因素动态骨髓车间设计的利基框架的协调运作多能干细胞和成熟细胞的时间表。以下总结了最近的报告在我们的理解突破校内的骨髓之间的关系细胞自噬介质和关键。autophagy-related的考虑无关的功能主要球员,比如p62,Atg7、Atg5 Beclin-1仍是一个引人注目的彻底理解复杂的任务异型的细胞类型之间的关系填充骨髓。

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