Laminin-derived peptide C16 regulates Tks expression and reactive oxygen species generation in human prostate cancer cells

Livia Caires-dos-Santos; Suely V. da Silva; Basilio SmuczekAdriane S. de SiqueiraKaren S. P. CruzJose Alexre M. BarbutoTaize M. AugustoVanessa M. FreitasHernes F. CarvalhoRuy G. Jaeger

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Laminin-derived peptide C16 regulates Tks expression and reactive oxygen species generation in human prostate cancer cells

机译：Laminin-derived肽C16调节谢谢表达式和活性氧生成在人类前列腺癌细胞

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Laminin peptides influence cancer biology. We investigated the role of a laminin-derived peptide C16 regulating invadopodia molecules in human prostate cancer cells (DU145). C16 augmented invadopodia activity of DU145 cells, and stimulated expression Tks4, Tks5, cortactin, and membrane-type matrix metalloproteinase 1. Reactive oxygen species generation is also related to invadopodia formation. This prompted us to address whether C16 would induce reactive oxygen species generation in DU145 cells. Quantitative fluorescence and flow cytometry showed that the peptide C16 increased reactive oxygen species in DU145 cells. Furthermore, significant colocalization between Tks5 and reactive oxygen species was observed in C16-treated cells. Results suggested that the peptide C16 increased Tks5 and reactive oxygen species in prostate cancer cells. The role of C16 increasing Tks and reactive oxygen species are novel findings on invadopodia activity.

机译：层粘连蛋白肽影响癌症生物学。调查laminin-derived的角色肽C16调节invadopodia分子人类前列腺癌细胞(DU145)。增强invadopodia DU145细胞的活动,和刺激表达式Tks4 Tks5 cortactin,和膜式基质金属蛋白酶1。活性氧生成也有关invadopodia形成。我们地址C16是否会诱导活性在DU145细胞氧物种的一代。定量荧光和流式细胞术表明,肽C16活性增加在DU145细胞氧物种。重大colocalization Tks5至活性氧是观察到C16-treated细胞。肽C16增加Tks5和活性氧物种在前列腺癌细胞。增加橡胶草和活性氧小说发现invadopodia活动。

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《Journal of cellular physiology.》 |2020年第1期|587-598|共12页
作者
Livia Caires-dos-Santos; Suely V. da Silva; Basilio SmuczekAdriane S. de SiqueiraKaren S. P. CruzJose Alexre M. BarbutoTaize M. AugustoVanessa M. FreitasHernes F. CarvalhoRuy G. Jaeger;
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Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao;

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正文语种英语
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关键词
Prostate Cancer; oxygen production; Extracellular MatrixDU145 cell linePodosomesLamininPeptidesCancer BiologyReactive Oxygen Species;

机译：前列腺癌;氧气生产;细胞外MatrixDU145细胞BiologyReactive氧物种;

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Laminin-derived peptide C16 regulates Tks expression and reactive oxygen species generation in human prostate cancer cells

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