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首页> 外文期刊>Journal of cellular physiology. >The endocannabinoid system modulates the ovarian physiology and its activation can improve in vitro oocyte maturation
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The endocannabinoid system modulates the ovarian physiology and its activation can improve in vitro oocyte maturation

机译：神经系统调节卵巢生理及其激活可以改善卵母细胞体外成熟

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摘要

The cannabinoid (CB) system has been involved in many aspects of reproduction and it is known that the systemic chronic use of exogenous CBs are deleterious to reproductive processes. Even so, it is not known what happens in relation to the physiology of the ovary when CB receptors are absent. The present study investigated the effect of the lack of CB1 and CB2 receptors in mice ovarian morphology, folliculogenesis, oocyte retrieval, and oocyte maturation and evaluated the use of A9-tetrahydrocannabinol (THC) on oocyte in vitro maturation (IVM) by comparing classical IVM and two-step IVM by analyzing the meiotic competence of the oocytes and their evolution toward embryos. Thus, when CB1 and CB2 receptors were missed, the ovary area and volume was significantly less and the action of the equine chorionic gonadotropin (eCG) hormone was diminished. In addition, the mutant genotypes had fewer ovarian follicles and they were less competent after eCG administration compared with wild-type mice, and this lack of CB receptors showed a mismatch of oocyte maturation. However, the in vitro use of THC showed improvements in oocytes IVM after a Pre-IVM step for 48 hr, as those oocytes reached a significantly higher polar body rate, a larger diameter and the best result on blastocysts rate was achieved when THC was used during the IVM step.
机译：大麻素(CB)系统参与了的许多方面,众所周知,再生产系统长期使用外源性CBs有害的生殖过程。现在还不知道会发生什么关系当CB受体卵巢的生理缺席。缺乏CB1和CB2受体的老鼠卵巢形态学,folliculogenesis,卵母细胞检索和卵母细胞成熟和评估使用A9-tetrahydrocannabinol (THC)卵母细胞体外成熟(IVM)进行比较通过分析古典IVM和两步IVM卵母细胞的减数分裂能力和他们的对胚胎进化。受体被错过,卵巢面积和体积显著减少的行动马绒毛膜促性腺激素(eCG)激素减少了。更少的卵泡和他们更少主管后心电图管理相比野生型老鼠,这缺乏CB受体显示不匹配的卵母细胞成熟。THC的体外使用显示的改进卵母细胞IVM Pre-IVM一步后48小时,这些卵母细胞达到更高极体率,一个更大的直径和最好的结果在囊胚率达到THC在IVM步骤。

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