...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of cellular physiology. >Exosome-mediated transfer of miR-1260b promotes cell invasion through Wnt/β-catenin signaling pathway in lung adenocarcinoma
【24h】

Exosome-mediated transfer of miR-1260b promotes cell invasion through Wnt/β-catenin signaling pathway in lung adenocarcinoma

机译：Exosome-mediated mir - 1260 b促进转移细胞入侵通过Wnt /β连环蛋白信号通路在肺腺癌

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Increasing evidence confirms that exosome-mediated transfer of microRNAs can influence cancer progression including tumor cell invasion, cell proliferation, and drug resistance via cell-cell communication. However, the potential role of exosomal-miR-1260b in lung adenocarcinoma (LAC) remains poorly understood. Thus, this study focused on investigating the function of exosomal-miR-1260b on cell invasion. Exosomal-miR-1260b was found to be higher in plasma of patients with LAC than that of healthy persons via quantitative real-time polymerase chain reaction assay. The sensitivity and specificity of exosomal-miR-1260b (cutoff point: 2.027) were 72% and 86%, and area under the curve of 0.845 (95% Cl = 0.772-0.922). Elevated expression of miR-1260b in LAC tissues was positively correlated with exosomal-miR-1260b in plasma (r=.642, p<.05). Furthermore, ceramide biosynthesis regulated exosomal-miR-1260b secretion. Exosome-mediated transfer of miR-1260b promoted A549 cell invasion and was still functional inside A549 cells. Moreover, exosomal-miR-1260b regulated Wnt/ β-catenin signaling pathway by inhibiting sFRP1 and Smad4. This study identified a new regulation mechanism involving in cell invasion by exosome-mediated tumor-cell-to-tumor-cell communication. Targeting exosome-microRNAs may provide new insights into the diagnosis and treatment of LAC.
机译：越来越多的证据证实exosome-mediated小分子核糖核酸可以影响癌症的转移发展包括肿瘤细胞入侵细胞通过信息扩散和耐药性沟通。exosomal - mir - 1260 b在肺腺癌(LAC)仍然知之甚少。重点调查的功能exosomal mir - 1260 b细胞入侵。exosomal - mir - 1260 b被发现在高等离子体的虫胶患者比健康人通过定量实时聚合酶连锁反应试验。特异性exosomal - mir - 1260 b(截点:2.027)分别为72%和86%,曲线下的面积0.845 (Cl 95% = 0.772 - -0.922)。mir - 1260 b的表达在虫胶组织积极与exosomal - mir - 1260 b等离子体(r =。生物合成调控exosomal mir - 1260 b分泌。提升A549细胞入侵和仍在A549细胞内部功能。exosomal - mir - 1260 b监管Wnt /β连环蛋白信号通路通过抑制sFRP1和Smad4。这项研究发现了一种新的监管机制涉及细胞由exosome-mediated入侵tumor-cell-to-tumor-cell沟通。exosome-microRNAs可能提供新的见解LAC的诊断和治疗。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号