...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of cellular physiology. >Breast cancer-derived exosomes: Tumor progression and therapeutic agents
【24h】

Breast cancer-derived exosomes: Tumor progression and therapeutic agents

机译：乳房cancer-derived液:肿瘤恶化和治疗药物

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Tumor cells secrete extracellular vesicles (EVs) for intercellular communication. EVs by transporting different proteins, nucleic acids, and lipids contribute to affect target cell function and fate. EVs which originate directly from multivesicular bodies so-called exosomes have dramatically fascinated the attention of researchers owing to their pivotal roles in the tumorigenesis. Breast cancer, arising from milk-producing cells, is the most identified cancer among women and has become the leading cause of cancer-related death in women globally. Although different therapies are applied to eliminate breast tumor cells, however, the efficient therapy and survival rate of patients remain challenges. Growing evidence shows exosomes from breast cancer cells contribute to proliferation, metastasis, angiogenesis, chemoresistance, and also radioresistance and, thus carcinogenesis. Additionally, these exosomes may serve as a cancer treatment tool because they are a good candidate for cancer diagnosis (as biomarker) and therapy (as drug-carrier). Despite recent development in the biology of tumor-derived exosomes, the detailed mechanism of tumorigenesis, and exosome-based cancer-therapy remain still indefinable. Here, we discuss the key function of breast cancer-derived exosomes in tumorgenesis and shed light on the possible clinical application of these exosomes in breast cancer treatment.
机译：肿瘤细胞分泌细胞外囊泡(EVs)细胞间的沟通。运输不同的蛋白质,核酸,和脂质导致影响靶细胞功能和命运。从多泡体所谓的液极大地吸引的注意吗研究人员由于他们的关键角色肿瘤发生。乳用细胞,是最确定的癌症,女性已成为领先的全球女性肿瘤相关性死亡的原因。尽管不同的疗法应用于然而,消除乳房肿瘤细胞有效的治疗和病人的存活率继续挑战。从乳腺癌细胞导致液扩散、转移、血管生成,药物抗性,抗辐射性,因此,致癌作用。可以作为癌症治疗的工具,因为他们吗是一个很好的候选人癌症诊断(如生物标志物)和治疗(药物传递)。生物学的最新发展tumor-derived液的具体机制肿瘤发生,exosome-based癌症治疗仍仍模糊不清的。乳房cancer-derived液囊的关键功能tumorgenesis和揭示的可能这些液在乳腺癌的临床应用癌症治疗。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号