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首页> 外文期刊>Journal of cellular physiology. >α5-nAChR modulates melanoma growth through the Notchl signaling pathway
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α5-nAChR modulates melanoma growth through the Notchl signaling pathway

机译：通过α5-nAChR调节黑色素瘤增长Notchl信号通路

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摘要

The roles of α5-nicotinic acetylcholine receptors (α5-nAChRs) in various types of solid cancer have been reported; however, its role in melanoma remains unknown. We knocked down α5-nAChR expression in melanoma cells to investigate the role of α5-nAChR in the proliferation, migration, and invasion of melanoma cells, and its effect on downstream signaling pathways. Using immunohistochemical analysis, we determined that α5-nAChR expression is significantly increased in human melanoma tissues and cell lines compared with normal human skin tissues. Knocking down α5-nAChR expression in melanoma cells in culture significantly inhibited the proliferation, migration, and invasiveness of melanoma cell lines. Specifically, knockdown of α5-nAChR inhibited PI3K-AKT and ERK1/2 signaling activity. Moreover, we confirmed that the Notchl signaling pathway is the downstream target of α5-nAChR in melanoma. Our findings suggest that α5-nAChR plays a critical role in melanoma development and progression, and that targeting α5-nAChR may be a strategy for melanoma treatment.
机译：角色的α5-nicotinic乙酰胆碱受体(α5-nAChRs)在各种类型的固体癌症据报道;仍然是未知的。黑色素瘤细胞中表达研究α的作用5-nAChR增殖,迁移,黑色素瘤细胞的入侵,其影响下游信号通路。免疫组织化学分析,我们确定α5-nAChR表达显著增加人类黑色素瘤组织和细胞系相比与正常人体皮肤组织。α5-nAChR黑色素瘤细胞中表达文化显著地抑制扩散,黑色素瘤细胞的迁移和侵袭性行。抑制PI3K-AKT和ERK1/2信号活动。此外,我们确认Notchl信号通路的下游目标α5-nAChR黑素瘤。在黑色素瘤的发展和中扮演一个关键的角色进展,针对α5-nAChR可能是一个黑色素瘤治疗的策略。

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