• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of cellular physiology. >GPX2 silencing relieves epithelial-mesenchymal transition, invasion, and metastasis in pancreatic cancer by down regulating Wnt pathway
【24h】

GPX2 silencing relieves epithelial-mesenchymal transition, invasion, and metastasis in pancreatic cancer by down regulating Wnt pathway

机译：GPX2压制缓解epithelial-mesenchymal过渡、入侵和转移胰腺癌的调节Wnt通路

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Glutathione peroxidase 2 (GPX2) participates in many cancers including pancreatic cancer (PC), and overexpression of GPX2 promotes tumor growth. Herein, we identified the role of GPX2 in epithelial-mesenchymal transformation (EMT), invasion, and metastasis in PC. Bioinformatics prediction was applied to select PC-related genes. The regulatory function of GPX2 in PC was explored by treatment with short hairpin RNA against GPX2 or LiCI (activator of wingless-type MMTV integration site [Wnt] pathway) in PC cells. GPX2 level in PC tissues, the levels of GPX2, β-catenin, Vimentin, Snail, epithelial-cadherin (E-cadherin), matrix metalloproteinase 2 (MMP2), MMP9, and Wnt2 in cells were determined. Subsequently, cell proliferation, invasion, and metastasis were assayed. Bioinformatics analysis revealed that GPX2 was involved in PC development mediated by the Wnt pathway. GPX2 was highly expressed in PC tissues. GPX2 silencing downregulated levels of (3-catenin, Vimentin, Snail, MMP2, MMP9, and Wnt2 but upregulated levels of E-cadherin. It was confirmed that GPX2 silencing suppressed PC cell proliferation, metastasis, and invasion. Furthermore, the trend of EMT and invasion and metastasis of PC induced by the LiCI-activated Wnt pathway was reversed when the GPX2 was silenced. GPX2 silencing could inhibit the Wnt pathway, subsequently suppress PC development.
机译：谷胱甘肽过氧化物酶2 (GPX2)参与许多癌症包括胰腺癌(PC),和超表达GPX2促进肿瘤的生长。在此,我们确认GPX2的作用epithelial-mesenchymal转换(EMT),入侵,在PC和转移。预测应用于选择个人电脑相关)基因。探索通过治疗短发卡RNA反对wingless-type GPX2或LiCI(活化剂MMTV集成网站Wnt通路)在PC细胞。PC GPX2水平组织,GPX2的水平,β连环蛋白、波形蛋白、蜗牛、epithelial-cadherin(钙)、基质金属蛋白酶2 (MMP2),MMP9, Wnt2细胞被确定。随后,细胞增殖、入侵和转移是化验。透露,GPX2参与个人电脑的发展Wnt通路介导的。表达了在PC组织。波形蛋白表达下调的水平(3-catenin,蜗牛,MMP2、MMP9和Wnt2但调节钙粘蛋白的水平。沉默抑制PC细胞增殖,转移和入侵。EMT的入侵和转移的PC诱导LiCI-activated Wnt通路被逆转当GPX2沉默。抑制Wnt通路,从而抑制PC发展。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号