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首页> 外文期刊>Journal of cellular physiology. >In silico genome-wide identification of m6A-associated SNPs as potential functional variants for periodontitis
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In silico genome-wide identification of m6A-associated SNPs as potential functional variants for periodontitis

机译：在硅全基因组的识别m6A-associated snp作为潜在的功能变异对牙周炎

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Genetic variation is considered to affect the N~6-methyladenosine (m6A) RNA transcript modification, which is the most prevalent posttranscriptional messenger RNA modification. This study aimed to identify m6A-associated single-nucleotide polymorphisms (m6A-SNPs) that may affect m6A methylation from numerous periodontitis (PD) SNPs. We identified an abundance of m6A-SNPs by analyzing raw data of published PD genome-wide association studies and m6A-SNPs list from the m6AVar database. Other evidence was found in public databases for expression quantitative trait loci (eQTL) and differential gene expression analysis. Accordingly, 1938 m6A-SNPs were identified, 104 of which appeared to be associated with PD (p < .05) while 65 showed eQTL signals. Lastly, the leading SNP rs2723183 (p = 3.93E-07) was predicted to regulate local gene IL-37 expression in PD (p = 2.64E-05; in GSE10334) and change regulatory motif RXRA. In summary, dozens of PD-associated m6A-SNPs were identified and their possible functions were demonstrated in this study.
机译：遗传变异被认为是影响N ~ 6-methyladenosine (m6A) RNA转录修改,这是最普遍的转录后的信使RNA修改。本研究旨在确定m6A-associated单核苷酸多态性(m6A-SNPs)从众多可能影响m6A甲基化牙周炎(PD)单核苷酸多态性。丰富的m6A-SNPs通过分析原始数据PD全基因组关联研究和出版m6A-SNPs从m6AVar数据库列表。证据被发现在公共数据库表达式(eQTL)和数量性状差异基因表达分析。因此,1938 m6A-SNPs被发现,104年这似乎与PD (p <. 05),而65年显示eQTL信号。领先的SNP rs2723183 e-07 (p = 3.93)预测控制当地的基因IL-37表达在PD (p = 2.64 e-05;监管RXRA主题。PD-associated m6A-SNPs识别和他们可能的功能演示研究。

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