...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of cellular physiology. >Long noncoding RNA PVT1: A highly dysregulated gene in malignancy
【24h】

Long noncoding RNA PVT1: A highly dysregulated gene in malignancy

机译：长非编码RNA PVT1:一个高度特异表达基因在恶性肿瘤

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent studies have verified the contribution of several long noncoding RNAs (IncRNAs) in the carcinogenesis. Among the highly acknowledged IncRNAs is the human homolog of the plasmacytoma variant translocation gene, which is called PVT1. PVT1 resides near Myc oncogene and regulates the oncogenic process through modulation of several signaling pathways, such as TGF-β, Wnt/ β-catenin, PI3K/AKT, and mTOR pathways. This IncRNA has a circular form as well. Expression analyses and functional studies have appraised the oncogenic roles of PVT1 and circPVTl. Experiments in several cancer cell lines have shown that PVT1 silencing suppresses cancer cell proliferation, whereas its overexpression has the opposite effect. Its silencing has led to the accumulation of cells in the G0/G1 phase and diminished the number of cells in the S phase. Moreover, genome-wide association studies have signified the role of single nucleotide polymorphisms of this IncRNA in conferring risk of lymphoma in different populations. In the current study, we have summarized recent data about the role of PVT1 and circPVTl in the carcinogenesis process.
机译：最近的研究证实的贡献几个长非编码rna (IncRNAs)致癌作用。IncRNAs是人类相同器官的浆细胞瘤被称为PVT1变体基因易位。PVT1 Myc癌基因和调节附近居住通过调制的几种致癌过程信号通路,比如TGF -β,Wnt /β连环蛋白,PI3K / AKT mTOR通路。IncRNA也一个圆形的形式。分析和功能研究评价PVT1和circPVTl的致癌作用。实验在一些癌症细胞系表明PVT1沉默抑制癌细胞扩散,而它的超表达相反的效果。细胞G0 / G1期和积累在S期细胞的数量减少。此外,全基因组关联研究表示单核苷酸的作用多态性的IncRNA赋予风险不同人群的淋巴瘤。目前的研究中,我们总结了最近的数据关于PVT1和circPVTl的角色致癌作用的过程。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号