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首页> 外文期刊>Journal of cellular physiology. >Factors, mechanisms and implications of chromatin condensation and chromosomal structural maintenance through the cell cycle
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Factors, mechanisms and implications of chromatin condensation and chromosomal structural maintenance through the cell cycle

机译：因素,机制和影响染色质凝结和染色体结构通过细胞周期维护

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摘要

A series of well-orchestrated events help in the chromatin condensation and the formation of chromosomes. Apart from the formation of chromosomes, maintenance of their structure is important, especially for the cell division. The structural maintenance of chromosome (SMC) proteins, the non-SMC proteins and the SMC complexes are critical for the maintenance of chromosome structure. While condensins have roles for the DNA compaction, organization, and segregation, the cohesin functions in a cyclic manner through the cell cycle, as a "cohesin cycle." Specific mechanisms maintain the architecture of the centromere, the kinetochore and the telomeres which are in tandem with the cell cycle checkpoints. The presence of chromosomal territories and compactness differences through the length of the chromosomes might have implications on selective susceptibility of specific chromosomes for induced genotoxicity.
机译：帮助一系列有序的事件染色质凝结形成的染色体。染色体,维护他们的结构重要的是,特别是对于细胞分裂。染色体的结构维护(SMC)蛋白质,non-SMC蛋白质和SMC复合物的维护至关重要染色体结构。DNA的压实、组织和隔离,cohesin函数在循环通过细胞周期的方式,为“cohesin周期。”架构的着丝点,着丝粒在串联和端粒细胞周期检查点。染色体的领土和密实度通过染色体的长度差异可能会对选择性的影响特定染色体的易感性诱导基因毒性。

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