...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of cellular physiology. >Hsa_circ_0039411 promotes tumorigenesis and progression of papillary thyroid cancer by miR-1179/ABCA9 and miR-1205/MTAl signaling pathways
【24h】

Hsa_circ_0039411 promotes tumorigenesis and progression of papillary thyroid cancer by miR-1179/ABCA9 and miR-1205/MTAl signaling pathways

机译：Hsa_circ_0039411促进肿瘤发生和乳头状甲状腺癌的进展mir - 1179 / ABCA9和mir - 1205 / MTAl信号通路

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Papillary thyroid cancer (PTC) is a common malignancy in endocrine system worldwide. Increasing evidence has shown that dysregulation of circular RNAs (circRNAs) could contribute to PTC tumorigenesis. The aims of this project are to investigate the potential role and molecular mechanism of hsa_circ_0039411 in PTC. In the project, RT-qPCR was performed to measure the expression profile of hsa_circ_0039411 in PTC tissues and cells. Cell counting kit-8, clonogenic, flow cytometric, and transwell experiments were used to identify the biological role of hsa_circ_0039411 on PTC cell progression. Bioinformatics methods, along with the dual-luciferase reporter test, was used to identify the potential mechanism of hsa_circ_0039411 Hsa_circ_0039411 was identified as enhanced in PTC tissues/cells. Gain-of-function experiments indicated that hsa_circ_0039411 facilitated PTC cell growth, migration, and invasion and inhibited cell apoptosis. Knockdown of hsa_circ_0039411 caused the opposite effects mentioned above. The mechanism exploration showed that hsa_circ_0039411 functioned as a sponge for miR-1179 and miR-1205 to elevate ATP-binding cassette transporter A9 (ABCA9) and metastasis-associated 1 (MTA1) expression at the post-transcriptional level, respectively. Further investigation confirmed that the functions of hsa_circ_0039411 are dependent on its modulation of ABCA9 and MTA1 in PTC cells. This study uncovered a mechanism of hsa_circ_0039411 in PTC, which might act as a novel therapeutic target for PTC.
机译：乳头状甲状腺癌(PTC)是一种常见的全球恶性肿瘤的内分泌系统。越来越多的证据表明失调圆形的rna (circRNAs)可能导致PTC肿瘤发生。调查潜在作用和分子在PTC hsa_circ_0039411机制。项目,RT-qPCR进行测量表达谱hsa_circ_0039411 PTC(列车自动控制系统)组织和细胞。单独使用、流量仪,transwell实验被用来识别的生物在PTC hsa_circ_0039411细胞进展的作用。生物信息学方法,以及dual-luciferase记者测试,用于识别的潜在机制hsa_circ_0039411 hsa_circ_0039411被确认PTC组织/细胞增强。功能实验表明,hsa_circ_0039411促进PTC细胞生长,迁移和入侵和抑制细胞细胞凋亡。上述相反的效果。机制的探索表明,hsa_circ_0039411是一块海绵mir - 1179和mir - 1205提升磷酸腺苷盒式运输车A9 (ABCA9)和在转移相关1 (MTA1)表达式转录后水平,分别。调查确认的功能hsa_circ_0039411依赖于它的调制ABCA9 MTA1的PTC细胞。发现了一个在PTC hsa_circ_0039411机制,,这可能成为新的治疗目标PTC。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号