Chitooligosaccharide inhibits RANKL-induced osteoclastogenesis and ligation-induced periodontitis by suppressing MAPK/ c-fos/NFATCl signaling

Weifeng Xu; Xinwei Chen; Yexin WangBaoting FanKe GuoChi YangShiqi YuYichuan PangShanyong Zhang

首页> 外文期刊>Journal of cellular physiology. >Chitooligosaccharide inhibits RANKL-induced osteoclastogenesis and ligation-induced periodontitis by suppressing MAPK/ c-fos/NFATCl signaling

【24h】

Chitooligosaccharide inhibits RANKL-induced osteoclastogenesis and ligation-induced periodontitis by suppressing MAPK/ c-fos/NFATCl signaling

机译：Chitooligosaccharide抑制RANKL-inducedosteoclastogenesis和ligation-induced牙周炎通过抑制MAPK / c-fos / NFATCl信号

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Considering the high rate of osteoclast-related diseases worldwide, research targeting osteoclast formation/function is crucial. In vitro, we demonstrated that chitooligosaccharide (CS) dramatically inhibited osteoclastogenesis as well as osteoclast function dose-dependently. CS suppressed osteoclast-specific genes expression during osteoclastogenesis. Furthermore, we found that CS attenuated receptor activator of nuclear factor kappa B ligand (RANKL)-mediated mitogen-activated protein kinase (MAPK) pathway involving p38, erk1/2, and jnk, leading to the reduced expression of c-fos and nuclear factor of activated T cells c1 (NFATcl) during osteoclast differentiation. In vivo, we found CS protected rats from periodontitis-induced alveolar bone loss by micro-computerized tomography and histological analysis. Overall, CS inhibited RANKL-induced osteoclastogenesis and ligature-induced rat periodontitis model, probably by suppressing the MAPK/ c-fos/NFATc1 signaling pathway. Therefore, CS may be a safe and promising treatment for osteoclast-related diseases.

机译：考虑到osteoclast-related率高疾病在世界范围内,研究针对破骨细胞形成/函数是至关重要的。证明chitooligosaccharide (CS)显著抑制osteoclastogenesis破骨细胞功能存在剂量依赖的相关性。抑制osteoclast-specific基因表达在osteoclastogenesis。CS减毒受体激活核因子k B配体(RANKL)介导的增殖蛋白激酶(MAPK)途径涉及p38 erk1/2物,导致的c-fos和核因子的表达式在破骨细胞激活T细胞c1 (NFATcl)分化。老鼠从periodontitis-induced牙槽骨micro-computerized断层和损失组织学分析。RANKL-induced osteoclastogenesis和ligature-induced大鼠牙周炎模型,可能通过抑制MAPK / c-fos / NFATc1信号通路。并承诺osteoclast-related治疗疾病。

著录项

来源
《Journal of cellular physiology.》 |2020年第3期|3022-3032|共11页
作者
Weifeng Xu; Xinwei Chen; Yexin WangBaoting FanKe GuoChi YangShiqi YuYichuan PangShanyong Zhang;
展开▼
作者单位

Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, College of Stomatology;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
Alveolar Bone Loss; Periodontitis; OsteoclastOsteoclastogenesisCHITOOLIGOSACCHARIDEosteoclast differentiation factor;

机译：牙槽骨丧失;牙周炎;OsteoclastOsteocl;

相似文献

外文文献
中文文献

1. Lentinula edodes extract inhibits matrix metalloproteinase expression and increases typeⅠprocollagen expression via the p38 MAPK/c-Fos signaling pathway in ultraviolet A and B-irradiated HaCaT keratinocytes [J] . Jung Im Lee, Jung Hwan Oh, Fatih Karadeniz, 亚太热带生物医学杂志：英文版 . 2021,第004期
2. Lentinula edodes extract inhibits matrix metalloproteinase expression and increases typeⅠprocollagen expression via the p38 MAPK/c-Fos signaling pathway in ultraviolet A and B-irradiated HaCaT keratinocytes [J] . Jung Im Lee, Jung Hwan Oh, Fatih Karadeniz, 亚太热带生物医学杂志（英文版） . 2021,第004期
3. TAZ inhibits osteoclastogenesis by attenuating TAK1/NF-κB signaling [J] . Wanlei Yang, Xuanyuan Lu, Tan Zhang, 骨研究：英文 . 2021,第003期
4. Sialoglycoproteins Isolated from the Eggs of Gadus morhua Inhibit Bone Resorption in Ovariectomized Rats by Suppressing the MAPK and NF-κB Pathways [J] . MAO Lei, WANG Yiming, WANG Meiling, 中国海洋大学学报（英文版） . 2019,第005期
5. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-kappa B and MAPK pathways [J] . Liao Shijie, Song Fangmin, Feng WenyuDing XiaofeiYao JunSong HuijieLiu YunMa ShitingWang ZiyiLin XixiXu JiakeZhao JinminLiu Qian Journal of cellular physiology. . 2019,第10aPta1期

机译：Rhoifolin改善钛particle-stimulated骨质溶解和减弱osteoclastogenesis通过RANKL-induced nf -κB和MAPK通路

Chitooligosaccharide inhibits RANKL-induced osteoclastogenesis and ligation-induced periodontitis by suppressing MAPK/ c-fos/NFATCl signaling

摘要

著录项

相似文献

相关主题

期刊订阅