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首页> 外文期刊>Journal of cellular physiology. >MicroRNA-188-5p promotes apoptosis and inhibits cell proliferation of breast cancer cells via the MAPK signaling pathway by targeting Rap2c
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MicroRNA-188-5p promotes apoptosis and inhibits cell proliferation of breast cancer cells via the MAPK signaling pathway by targeting Rap2c

机译：微rna - 188 - 5 - p促进细胞凋亡和抑制乳腺癌细胞通过细胞增殖针对Rap2c MAPK信号通路

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摘要

Breast cancer is a common malignancy that is highly lethal with poor survival rates and immature therapeutics that urgently needs more effective and efficient therapies. MicroRNAs are intrinsically involved in different cancer remedies, but their mechanism in breast cancer has not been elucidated for prospective treatment. The function and mechanism of microRNA-188-5p (miR-188) have not been thoroughly investigated in breast cancer. In our study, we found that the expression of miR-188 in breast cancer tissues was obviously reduced. Our findings also revealed the abnormal overexpression of miR-188 in 4T1 and MCF-7 cells significantly suppressed cell proliferation and migration and also enhanced apoptosis. miR-188 induced cell cycle arrest in the G1 phase. To illuminate the molecular mechanism of miR-188, Rap2c was screened as a single target gene by bioinformatics database analysis and was further confirmed by dual-luciferase assay. Moreover, Rap2c was found to be a vital molecular switch for the mitogen-activated protein kinase signaling pathway in tumor progression by decreasing apoptosis and promoting proliferation and migration. In conclusion, our results revealed that miR-188 is a cancer progression suppressor and a promising future target for breast cancer therapy.
机译：乳腺癌是一种常见的恶性肿瘤高度致命的存活率和较差不成熟的疗法,迫切需要更多的有效的和有效的治疗方法。本质上涉及不同的癌症在乳腺癌的补救措施,但其机制没有阐明未来吗治疗。微rna - 188 - 5 - p (mir - 188)没有彻底调查乳腺癌。研究中,我们发现mir - 188的表达乳腺癌组织明显减少。调查结果还显示不正常超表达4 t1和MCF-7 mir - 188的细胞显著抑制细胞增殖迁移,也增强了细胞凋亡。诱导细胞周期阻滞在G1期。照亮mir - 188的分子机制,Rap2c单个目标基因的筛选生物信息学数据库分析和进一步证实了dual-luciferase化验。Rap2c被发现是一个重要的分子开关增殖作用的蛋白激酶信号通路在肿瘤进展减少细胞凋亡和促进增殖和迁移。透露,mir - 188是一个癌症恶化抑制器和一个有前途的未来的目标乳腺癌的治疗。

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