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首页> 外文期刊>Journal of cellular physiology. >Loss of interleukin-10 exacerbates early Type-1 diabetes-induced bone loss
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Loss of interleukin-10 exacerbates early Type-1 diabetes-induced bone loss

机译：白细胞介素- 10”加剧了早期1型的损失diabetes-induced骨质流失

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摘要

Type-1 diabetes (T1D) increases systemic inflammation, bone loss, and risk for bone fractures. Levels of the anti-inflammatory cytokine interleukin-10 (IL-10) are decreased in T1D, however their role in TID-induced osteoporosis is unknown. To address this, diabetes was induced in male IL-10 knockout (KO) and wild-type (WT) mice. Analyses of femur and vertebral trabecular bone volume fraction identified bone loss in T1D-WT mice at 4 and 12 weeks, which in T1D-IL-10-KO mice was further reduced at 4 weeks but not 12 weeks. IL-10 deficiency also increased the negative effects of T1D on cortical bone. Osteoblast marker osterix was decreased, while osteoclast markers were unchanged, suggesting that IL-10 promotes anabolic processes. MC3T3-E1 osteoblasts cultured under high glucose conditions displayed a decrease in osterix which was prevented by addition of IL-10. Taken together, our results suggest that IL-10 is important for promoting osteoblast maturation and reducing bone loss during early stages of T1D.
机译：1型糖尿病(近年来增加系统性炎症、骨质疏松和骨的风险骨折。细胞因子白细胞介素- 10”(il - 10)是减少的近年来,但是他们的角色在TID-induced骨质疏松症是未知的。糖尿病是导致男性il - 10基因敲除(KO)和野生型小鼠(WT)。椎体骨小梁体积分数确定在T1D-WT小鼠骨质疏松4和12周,T1D-IL-10-KO老鼠进一步减少在4周而不是12周。缺乏也增加了的负面影响近年来在皮质骨。下降,而破骨细胞标记吗不变,表明il - 10促进合成代谢过程。在高葡萄糖条件下显示减少osterix阻止的il - 10。表明,il - 10对推广很重要成骨细胞的成熟和减少骨质流失在近年来的早期阶段。

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