Role of forkhead box gene family in bone metabolism

Jinjing Huang; Gengyang Shen; Hui RenZhida ZhangXiang YuWenhua ZhaoQi ShangJianchao CuiPeiyuan YuJiancheng PengDe LiangZhidong YangXiaobing Jiang

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Role of forkhead box gene family in bone metabolism

机译：forkhead盒基因家族在骨头新陈代谢

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Bone metabolism is associated with many bone diseases and regulated by multiple signal pathways. Over the past three decades, the functions of a superfamily of evolutionarily conserved transcriptional regulators, known as forkhead box (Fox) family, has been demonstrated to contribute to the bone metabolism. Genetic analysis studies have demonstrated that Fox gene family participate in bone metabolism and that their expression can be regulated by multiple factors. The deregulation of Fox gene family can lead to a series of bone metabolic diseases. In this manuscript, we sketched the biology of the Foxs family, summarized its function of regulating bone metabolism and maintaining bone homeostasis to estimate its potential therapeutic effects in bone diseases, and suggested directions for future exploration in this important field.

机译：与许多骨骨代谢相关联疾病和由多个信号通路。总科的进化功能守恒的转录监管机构,称为forkhead框(福克斯)的家庭,已经证明了有助于骨骼的新陈代谢。分析研究已经证明,福克斯基因家庭参与骨代谢他们可以由多个表达式的因素。导致一系列的骨代谢疾病。这个手稿,我们勾勒的生物学绝大部分家庭,总结了其功能调节骨代谢和维持骨内稳态估计其潜在的治疗在骨骼疾病影响,建议对未来的探索方向重要的领域。

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来源
《Journal of cellular physiology.》 |2020年第3期|1986-1994|共9页
作者
Jinjing Huang; Gengyang Shen; Hui RenZhida ZhangXiang YuWenhua ZhaoQi ShangJianchao CuiPeiyuan YuJiancheng PengDe LiangZhidong YangXiaobing Jiang;
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作者单位

Guangzhou University of Chinese Medicine, Guangzhou, China;

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正文语种英语
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关键词
Bone Diseases; Buxus sempervirens; Foxmultiple signalfamilybone metabolism;

机译：骨骼疾病,进行了它们;Foxmultiplesignalfamilybone新陈代谢;

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Role of forkhead box gene family in bone metabolism

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