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首页> 外文期刊>Journal of cellular physiology. >Modulation of autophagy in traumatic brain injury
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Modulation of autophagy in traumatic brain injury

机译：自噬在创伤性脑损伤的调制

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Traumatic brain injury (TBI) is defined as a traumatically induced structural injury or physiological disruption of brain function as a result of external forces, leading to adult disability and death. A growing body of evidence reveals that alterations in autophagy-related proteins exist extensively in both experimentally and clinically after TBI. Of note, the autophagy pathway plays an essential role in pathophysio-logical processes, such as oxidative stress, inflammatory response, and apoptosis, thus contributing to neurological properties of TBI. With this in mind, this review summarizes a comprehensive overview on the beneficial and detrimental effects of autophagy in pathophysiological conditions and how these activities are linked to the pathogenesis of TBI. Moreover, the relationship between oxidative stress, inflammation, apoptosis, and autophagy occur TBI. Ultimately, multiple compounds and various drugs targeting the autophagy pathway are well described in TBI. Therefore, autophagy flux represents a potential clinical therapeutic value for the treatment of TBI and its complications.
机译：创伤性脑损伤(TBI)被定义为一个去撞墙诱导结构损伤或大脑功能的生理干扰外部力量的结果,导致成人残疾和死亡。显示,在autophagy-related改变蛋白广泛存在于这两个实验创伤性脑损伤后,临床诊断。途径中扮演着重要的角色pathophysio-logical流程,如氧化压力、炎症反应和细胞凋亡,从而导致神经系统的性质创伤性脑损伤。有益的和全面的概述自噬的不利影响病理生理条件和如何将这些活动与创伤性脑损伤的发病机制有关。此外,氧化之间的关系压力、炎症、细胞凋亡和自噬创伤性脑损伤的发生。各种药物针对自噬通路创伤性脑损伤中描述。代表了一种潜在的临床治疗价值治疗创伤性脑损伤和并发症。

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