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首页> 外文期刊>Journal of cellular physiology. >Complicated trafficking behaviors involved in paradoxical regulation of sortilin in lipid metabolism
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Complicated trafficking behaviors involved in paradoxical regulation of sortilin in lipid metabolism

机译：参与复杂的交易行为矛盾的调节sortilin脂质新陈代谢

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This review aims to summarize and discuss the most recent advances in our understanding of the underlying mechanisms of the paradoxical effects of sortilin on lipid metabolism. The vacuolar protein sorting 10 protein (VpslOp) domain in the sortilin protein is responsible for substrate binding. Its cytoplasmic tail interacts with adaptor molecules, and modifications can determine whether sortilin trafficking occurs via the anterograde or retrograde pathway. The complicated trafficking behaviors likely contribute to the paradoxical roles of sortilin in lipid metabolism. The anterograde pathway of sortilin trafficking in hepatocytes, enterocytes, and peripheral cells likely causes an increase in plasma lipid levels, while the retrograde pathway leads to the opposite effect. Hepatocyte sortilin functions via the anterograde or retrograde pathway in a complicated and paradoxical manner to regulate apoB-containing lipoprotein metabolism. Clarifying the regulatory mechanisms underlying the trafficking behaviors of sortilin is necessary and may lead to artificial sortilin intervention as a potential therapeutic strategy for lipid disorder diseases. Conclusively, the paradoxical regulation of sortilin in lipid metabolism is likely due to its complicated trafficking behaviors.
机译：本文旨在总结和讨论我们理解的最新进展潜在机制的矛盾的影响sortilin脂质代谢。蛋白质分选10 (VpslOp)域的sortilin蛋白质负责衬底绑定。适配器的分子,和修改确定sortilin贩卖发生通过顺行或逆行通道。复杂的交易行为可能导致sortilin的矛盾的角色在脂类代谢。sortilin贩卖肝细胞、肠上皮细胞和外围细胞可能会导致增加血浆脂质水平,而逆行通道会导致相反的效果。函数通过顺行或逆行通路的复杂和矛盾的方式调节apoB-containing脂蛋白新陈代谢。底层sortilin的走私行为是必要的和可能导致人工sortilin吗干预作为一个潜在的治疗策略脂质紊乱疾病。矛盾的调节sortilin脂质代谢可能是由于其复杂走私行为。

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