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首页> 外文期刊>Journal of cellular physiology. >Androgen receptor-related micro RNAs in prostate cancer and their role in antiandrogen drug resistance
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Androgen receptor-related micro RNAs in prostate cancer and their role in antiandrogen drug resistance

机译：在前列腺癌雄激素受体相关微rna癌症和抗雄激素药物的作用电阻

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摘要

Prostate cancer (PCa) is one of the most common cancers and the fifth most common reason for cancer deaths in the males. Surgical castration combined with androgen deprivation therapy, antiandrogens, and androgen synthesis inhibitors is the current therapeutic modalities for PCa. These strategies inhibit androgen synthesis or reduce its binding to the androgen receptor (AR) but the development of resistance to these therapies and transient responsiveness are challenging issues in the treatment of this cancer. Deregulation of ARs has a vital role in the initiation and progression of PCa. Also, recent findings imply that micro RNAs (miRNAs) are involved in the evolution of PCa and mediate drug resistance in different cancers. Hence, discovering and targeting miRNAs might represent a novel therapeutic approach. This review paid particular attention to the AR pathway and existing information on the possible roles of miRNAs associated with AR pathway and drug resistance to two second-generation antiandrogens, that is, enzalutamide and abiraterone.
机译：前列腺癌(PCa)是最常见的一种癌症和第五个最常见的原因在男性癌症死亡。雄激素剥夺疗法相结合,抗雄激素,雄激素合成抑制剂是目前治疗对PCa方法。这些策略或抑制雄激素的合成减少对雄激素受体(AR)的绑定但这些阻力的发展治疗和瞬态响应治疗这一具有挑战性的问题癌症。PCa的发生和发展。最近的研究表明微rna (microrna)参与PCa的进化和调解吗在不同的肿瘤耐药。发现和定位microrna可能代表一种新的治疗方法。特别注意的基于“增大化现实”技术的途径现有的角色的信息microrna与基于“增大化现实”技术的途径和药物有关抵抗两代抗雄激素,enzalutamide和abiraterone。

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