LncRNAs as potential diagnostic and prognostic biomarkers in gastric cancer: A novel approach to personalized medicine

Sadegh Fattahi; Mohadeseh Kosari-Monfared; Monireh GolpourZakieh EmamiMohammad GhasemiyanMaryam NouriHaleh Akhavan-Niaki

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LncRNAs as potential diagnostic and prognostic biomarkers in gastric cancer: A novel approach to personalized medicine

机译：LncRNAs作为潜在的诊断和预后生物标志物在胃癌:一种新颖的方式个性化医疗

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Gastric cancer is the third leading cause of cancer death with 5-year survival rate of about 30-35%. Since early detection is associated with decreased mortality, identification of novel biomarkers for early diagnosis and proper management of patients with the best response to therapy is urgently needed. Long noncoding RNAs (IncRNAs) due to their high specificity, easy accessibility in a noninvasive manner, as well as their aberrant expression under different pathological and physiological conditions, have received a great attention as potential diagnostic, prognostic, or predictive biomarkers. They may also serve as targets for treating gastric cancer. In this review, we highlighted the role of IncRNAs as tumor suppressors or oncogenes that make them potential biomarkers for the diagnosis and prognosis of gastric cancer. Relatively, IncRNAs such as H19, HOTAIR, UCA1, PVT1, tissue differentiation-inducing nonprotein coding, and UNC00152 could be potential diagnostic and prognostic markers in patients with gastric cancer. Also, the impact of IncRNAs such as ecCEBPA, MLK7-AS1, TUG1, HOXA11-AS, GAPLINC, LEIGC, multidrug resistance-related and upregulated IncRNA, PVT1 on gastric cancer epigenetic and drug resistance as well as their potential as therapeutic targets for personalized medicine was discussed.

机译：胃癌是第三个的主要原因癌症死亡的5年生存率30 - 35%。降低死亡率,小说的识别生物标志物早期诊断和适当的管理的患者最好的回应治疗是急需的。(IncRNAs)由于其高特异性,容易可访问性非侵入性的方式,以及其异常表达在不同病理和生理条件得到了极大关注的潜力诊断、预后或预测生物标志物。他们也可能作为治疗目标胃癌。IncRNAs作为肿瘤抑制或的角色致癌基因,使它们的潜在生物标志物胃癌的诊断和预后。相对,IncRNAs如段H19,热空气,UCA1,differentiation-inducing非蛋白PVT1,组织编码和UNC00152可能是潜在的诊断和预后标记的病人与胃癌。如ecCEBPA、MLK7-AS1 TUG1 HOXA11-AS,GAPLINC LEIGC,多重resistance-related和调节IncRNA, PVT1胃癌表观遗传和耐药性以及他们潜在作为个性化的治疗靶点讨论了医学。

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《Journal of cellular physiology.》 |2020年第4期|3189-3206|共18页
作者
Sadegh Fattahi; Mohadeseh Kosari-Monfared; Monireh GolpourZakieh EmamiMohammad GhasemiyanMaryam NouriHaleh Akhavan-Niaki;
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Department of Genetics, Student Research Committee, Babol University of Medical Sciences, Babol;

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正文语种英语
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Prognostic Marker; Long Intergenic Non-Protein Coding RNA; EpigeneticsBiological MarkersEarly DiagnosisPrecision MedicineCancer of Stomach;

机译：基因间非蛋白预后标记;长编码RNA;EpigeneticsBiological MarkersEarlyDiagnosisPrecision MedicineCancer的胃;

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LncRNAs as potential diagnostic and prognostic biomarkers in gastric cancer: A novel approach to personalized medicine

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