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首页> 外文期刊>Journal of cellular physiology. >Modulatory effects of statins on the autophagy: A therapeutic perspective
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Modulatory effects of statins on the autophagy: A therapeutic perspective

机译：调节自噬:他汀类药物的影响治疗的角度来看

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Autophagy is considered as an important mechanism for maintaining homeostasis and responsible for the degradation of superfluous or potentially toxic components and organelles. Autophagy impairment is associated with a number of pathological conditions, such as aging, neurological disorders, cancer, and infection. Autophagy also plays a significant role in cancer chemotherapy. The multiple cancer drugs have been notably developed with the strategy of autophagy modulation. Statins, 3-hydroxy-3-methyl-glutaryl-CoA inhibitors, are known due to their efficacy in decreasing low-density lipoprotein and extensively used for the management of cardiovascular diseases. Statins have other therapeutic and biological activities, such as antioxidant, anti-inflammatory, antitumor, and neuroprotective known as pleiotropic effects. It seems that statins are capable of targeting various signaling pathways in the induction of their great pharmacological effects. At the present study, we demonstrate the therapeutic effects of statins mediated via autophagy regulation.
机译：自噬是一个重要的机制维持体内平衡和负责多余的或者潜在的降解有毒的组件和细胞器。损伤与许多相关病理条件下,如老化、神经系统疾病、癌症和感染。自噬还在癌症中起着重要作用化疗。尤其是发达与自噬的策略调制。3-hydroxy-3-methyl-glutaryl-CoA抑制剂,由于其疗效降低低密度脂蛋白和广泛的用途心血管疾病的管理。他汀类药物有其他治疗和生物活动,如抗氧化剂,抗炎、抗肿瘤、神经保护被称为多效性的影响。他汀类药物能够针对不同信号通路的感应伟大的药理作用。研究中,我们演示的治疗效果他汀类药物通过自噬调节介导。

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