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首页> 外文期刊>Journal of cellular physiology. >MiR-142-3p functions as a tumor suppressor by targeting RAC1/PAK1 pathway in breast cancer
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MiR-142-3p functions as a tumor suppressor by targeting RAC1/PAK1 pathway in breast cancer

机译：mir - 142 - 3 - p作为肿瘤抑制功能针对RAC1 / PAK1通路在乳腺癌

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摘要

MicroRNA-142-3p (miR-142-3p) was previously investigated in various cancers, whereas, it's role in breast cancer (BC) remains far from understood. In this study, we found that miR-142-3p was markedly decreased both in cell lines and BC tumor tissues. Elevated miR-142-3p expression suppressed growth and metastasis of BC cell lines via gain-of-function assay in vitro and in vivo. Mechanistically, miR-142-3p could regulate the ras-related C3 botulinum toxin substrate 1 (RAC1) expression in protein level, which simultaneously suppressed the epithelial-to-mesenchymal transition related protein levels and the activity of PAK1 phosphorylation, respectively. In addition, rescue experiments revealed RAC1 overexpression could reverse tumor-suppressive role of miR-142-3p. Our results showed miR-142-3p could function as a tumor suppressor via targeting RAC1/PAK1 pathway in BC, suggesting a potent therapeutic target for BC treatment.
机译：微rna - 142 - 3 - p (mir - 142 - 3 - p)之前研究了各种癌症,而它的角色在乳腺癌(BC)仍然远离理解。mir - 142 - 3 - p是在细胞都明显减少线条和BC肿瘤组织。公元前的表达抑制生长和转移通过功能分析体外细胞系和体内。调节ras-related C3肉毒杆菌毒素基板1 (RAC1)在蛋白质水平表达,这同时抑制epithelial-to-mesenchymal过渡相关的蛋白质含量和PAK1的活动分别磷酸化。救援实验显示RAC1超表达逆转肿瘤抑制作用的mir - 142 - 3 - p。通过目标函数作为一个肿瘤抑制公元前RAC1 / PAK1通路,暗示的公元前的治疗目标治疗。

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