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首页> 外文期刊>Journal of cellular physiology. >Outer membrane vesicles enhance tau phosphorylation and contribute to cognitive impairment
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Outer membrane vesicles enhance tau phosphorylation and contribute to cognitive impairment

机译：外膜囊泡增强τ磷酸化和认知障碍

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摘要

Outer membrane vesicles (OMVs) are nanosized vesicles produced by the gut microbiota (GM). The GM is well-known to be involved in the pathological process of Alzheimer's disease (AD). However, the mechanism of OMVs is not clear. In the present study, we demonstrated the involvement of OMVs in the development of cognitive (learning and memory) dysfunction induced by blood-brain barrier (BBB) disruption. More important, further study showed that OMVs induced tau phosphorylation by activating glycogen synthase kinase 3β (GSK-3β) in the hippocampus. OMVs activated astrocytes and microglia, increased secretion of inflammatory cytokines (nuclear factor kB, interleukin-1β, and tumour necrosis factor-α) in the hippocampus. Therefore, OMVs increase the permeability of the BBB and promote the activation of astrocytes and microglia, inducing an inflammatory response and tau hyperphosphorylation by activating the GSK-3β pathway and finally leading to cognitive impairment.
机译：外膜小泡(omv)是纳米尺度的囊泡产生的肠道微生物群(通用)。通用汽车是著名的参与阿尔茨海默病(AD)的病理过程。然而,omv的机制还不清楚。目前的研究中,我们展示了omv参与的发展认知学习和记忆功能障碍引起血脑屏障(BBB)破坏。更重要的是,进一步的研究表明,omv诱导τ磷酸化通过激活糖原合成酶激酶3β(GSK-3β)海马体。小神经胶质细胞、炎性分泌物的增加细胞因子(核因子kB, interleukin-1β,肿瘤坏死因子-α)在海马。因此,omv的渗透性增加BBB和促进星形胶质细胞的激活和小神经胶质细胞,诱导炎症反应和τhyperphosphorylation通过激活GSK-3β途径,最终导致认知障碍。

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