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首页> 外文期刊>Journal of cellular physiology. >Combined effects of avasimibe immunotherapy, doxorubicin chemotherapy, and metal-organic frameworks nanoparticles on breast cancer
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Combined effects of avasimibe immunotherapy, doxorubicin chemotherapy, and metal-organic frameworks nanoparticles on breast cancer

机译：结合avasimibe免疫治疗的影响,阿霉素化疗,有机配合纳米颗粒对乳腺癌的框架

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CD8+ T cells play a vital role in cancer immunotherapy and can be shaped by metabolism. Avasimibe is an acyl coenzyme A-cholesterol acyltransferase (ACAT) inhibitor, which has been clinically verified safe in other phase III clinical trials. It can potentiate the killing function of CD8+ T cells by modulating cholesterol metabolism. Doxorubicin (DOX) is an anticancer drug widely used in many cancers to induce tumor cell apoptosis. Unfortunately, DOX also can induce toxic and side effects in many organs, compromising its usage and efficacy. Herein, we report the combinational usage of avasimibe and a safe pH sensitive nano-drug delivery system composing of DOX and metal-organic frameworks nanoparticles (MNPs). Our findings demonstrated that DOX-MNPs treatment inhibited tumor growth with good safety profile and avasimibe treatment combined DOX-MNPs treatment exhibited a better efficacy than monotherapies in 4T1 breast cancer therapy.
机译：CD8 + T细胞在癌症起到至关重要的作用免疫疗法,可以由新陈代谢。Avasimibe酰基辅酶胆固醇酰基转移酶(ACAT)抑制剂,在其他III期临床验证安全临床试验函数调制的CD8 + T细胞胆固醇代谢。抗癌药物广泛应用于许多癌症诱导肿瘤细胞凋亡。也能导致许多毒性和副作用器官,牺牲其用法和有效性。在此,我们报告的组合使用nano-drug avasimibe pH值和一个安全的敏感系统组成的强力霉素和交付有机框架纳米颗粒(基于)。我们的研究结果表明,DOX-MNPs治疗抑制肿瘤的生长具有良好的安全性并结合DOX-MNPs avasimibe治疗治疗效果比展出单一药物疗法在4 t1乳腺癌治疗。

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