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首页> 外文期刊>Journal of cellular physiology. >Long noncoding RNA VCAN-AS1 contributes to the progression of gastric cancer via regulating p53 expression
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Long noncoding RNA VCAN-AS1 contributes to the progression of gastric cancer via regulating p53 expression

机译：长非编码RNA VCAN-AS1有助于通过调节胃癌p53的进展表达式

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摘要

Gastric cancer (GC) is one of the most frequent malignancies worldwide. Long noncoding RNAs (IncRNAs) are found to be largely implicated in various cancers, including GC. However, the function of IncRNA VCAN antisense RNA 1 (VCAN-AS1) in GC remains unclear. Herein, we observed a low level of VCAN-AS1 in normal gastric tissues through NCBI and UCSC, and that VCAN-AS1 upregulation in GC tissues was related to poor prognosis by TCGA. Furthermore, VCAN-AS1 was found markedly enhanced in GC tissues and cell lines, while its upregulation was related with clinical outcomes of GC patients. Besides this, silencing VCAN-AS1 represses cell proliferation, migration, and invasion but enhances apoptosis. More important, we discovered that VCAN-AS1 expression was negatively correlated with wild-type p53 levels in GC tissues and that p53 was negatively modulated by VCAN-AS1 in GC cells. Furthermore, p53 suppression reversed the repression of VCAN-AS1 silence on the biological processes of AGS cells. Intriguingly, we identified that both VCAN-AS1 and TP53 can bind with elF4A3, one of the core proteins in the exon junction complex. Also, we confirmed that VCAN-AS1 negatively regulates TP53 expression by competitively binding with elF4A3. Our findings disclosed that VCAN-AS1 contributes to GC progression through interacting with elF4A3 to downregulate TP53 expression, indicating that VCAN-AS1 is a novel therapeutic strategy for GC treatment.
机译：胃癌(GC)是最常见的之一全球恶性肿瘤。(IncRNAs)发现很大程度上涉及各种癌症,包括GC。的函数IncRNA VCAN反义RNA 1GC (VCAN-AS1)仍不清楚。观察到一个低水平的VCAN-AS1在正常胃组织通过NCBI UCSC的,在GC VCAN-AS1 upregulation组织有关通过,TCGA预后不良。被发现在GC显著增强组织和细胞系,而其upregulation有关GC患者的临床结果。这沉默VCAN-AS1压制细胞增殖、迁移和入侵增强了细胞凋亡。VCAN-AS1表达式是消极的与野生型p53在GC水平组织和p53负面调制在GC VCAN-AS1细胞。抑制了VCAN-AS1的镇压沉默在AGS细胞的生物学过程。有趣的是,我们发现这两种VCAN-AS1并与elF4A3 TP53可以绑定,核心之一蛋白质的外显子结复杂。确认VCAN-AS1负调节TP53表达式由竞争性与elF4A3绑定。我们的发现透露,VCAN-AS1贡献通过与elF4A3交互GC进展表达下调TP53的表达,表明VCAN-AS1 GC是一种新的治疗策略治疗。

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