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首页> 外文期刊>Journal of cellular physiology. >Prospects for the involvement of cancer stem cells in the pathogenesis of osteosarcoma
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Prospects for the involvement of cancer stem cells in the pathogenesis of osteosarcoma

机译：癌症干细胞的参与的前景在骨肉瘤的发病机制

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摘要

Osteosarcoma (OS) is one of the most common bone tumors in children and adolescents that cause a high rate of mortality in this age group and tends to be metastatic, in spite of chemotherapy and surgery. The main reason for this can be returned to a small group of malignant cells called cancer stem cells (CSCs). OS-CSCs play a key role in the resistance to treatment and relapse and metastasis through self-renewal and differentiation abilities. In this review, we intend to go through the different aspects of this malignant disease, including the cancer stem cell-phenotype, methods for isolating CSCs, signaling pathways, and molecular markers in this disease, and drugs showing resistance in treatment efforts of OS.
机译：骨肉瘤(OS)是最常见的一种骨头肿瘤导致的儿童和青少年在这个年龄段和高死亡率倾向于转移性,尽管化疗和手术。回到了一小群恶性细胞被称为癌症干细胞(二者)。在抵抗治疗和关键的作用通过自我更新和复发和转移分化的能力。打算穿过的不同方面这种恶性疾病,包括癌症干细胞cell-phenotype,隔离二者的方法,信号通路和分子标记疾病和药物出现耐药性治疗工作的操作系统。

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