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首页> 外文期刊>Journal of cellular physiology. >Colon cancer therapy by focusing on colon cancer stem cells and their tumor microenvironment
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Colon cancer therapy by focusing on colon cancer stem cells and their tumor microenvironment

机译：结肠癌治疗通过专注于结肠癌肿瘤干细胞及其微环境

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摘要

Despite many advances and optimization in colon cancer treatment, tumor recurrence and metastases make the development of new therapies necessary. Colon cancer stem cells (CCSCs) are considered as the main triggering factor of cancer progression, recurrence, and metastasis. CCSCs as a result of accumulated genetic and epigenetic alterations and also complex interconnection with the tumor microenvironment (TME) can evolve and convert to full malignant cells. Mounting evidence suggests that in cancer therapy both CCSCs and non-CCSCs in TME have to be regarded to break through the limitation of current therapies. In this regard, stem cell capabilities of some non-CCSCs may arise inside the TME condition. Therefore, a deep knowledge of regulatory mechanisms, heterogeneity, specific markers, and signaling pathways of CCSCs and their interconnection with TME components is needed to improve the treatment of colorectal cancer and the patient's life quality. In this review, we address current different targeted therapeutic options that target cell surface markers and signaling pathways of CCSCs and other components of TME. Current challenges and future perspectives of colon cancer personalized therapy are also provided here. Taken together, based on the deep understanding of biology of CCSCs and using three-dimensional culture technologies, it can be possible to reach successful colon cancer eradication and improvise combination targeted therapies against CCSCs and TME.
机译：尽管许多进步和优化在结肠癌症治疗,肿瘤复发和转移使新疗法的发展必要的。结肠癌干细胞(CCSCs)被认为是癌症恶化的主要诱因,复发和转移。积累的遗传和表观遗传变化并与肿瘤复杂的互连微环境(时间)可以发展和转换完整的恶性细胞。在癌症治疗CCSCs和non-CCSCs在时间必须被打破限制电流疗法。一些non-CCSCs可能的干细胞功能出现在时间条件。知识的监管机制,异质性、特定的标记和信号通路CCSCs及其互连开心的组件需要改善治疗结直肠癌病人的生命质量。不同的有针对性的治疗选项靶细胞表面标记和信号CCSCs通路和其他组件的时间。当前的挑战和未来的视角结肠癌个性化疗法也这里提供。CCSCs生物学的理解和使用三维文化技术,它可以结肠癌可能达到成功根除和即兴创作组合的目标治疗对CCSCs和时间。

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