Resveratrol targeting the Wnt signaling pathway: A focus on therapeutic activities

Milad Ashrafizadeh; Zahra Ahmadi; Tahereh FarkhondehSaeed Samarghian

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Resveratrol targeting the Wnt signaling pathway: A focus on therapeutic activities

机译：白藜芦醇针对Wnt信号通路:专注于治疗性活动

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Wingless-type MMTV integration site (Wnt) signaling pathway is considered as an important pathway regulating a variety of biological processes such as tissue formation and homeostasis, cell proliferation, cell migration, cell differentiation, and embryogenesis. Impairment in the Wnt signaling pathway is associated with pathological conditions, particularly cancer. So, modulation of this pathway can be considered as a promising strategy and several drugs have been developed in line with this strategy. Resveratrol (Res) is a naturally occurring nutraceutical compound exclusively found in different fruits and nuts such as grape, peanut, and pistachio. This compound has favorable biological and therapeutic activities such as antioxidant, anti-inflammatory, antitumor, hepatoprotective, cardioprotective, and antidiabetic. At the present review, we demonstrate how Res modulates Wnt signaling pathway to exert its pharmacological effects.

机译：Wingless-type MMTV集成网站(Wnt)信号通路被认为是一个重要的通路调节各种各样的生物过程,如组织形成和体内平衡、细胞增殖、细胞迁移,细胞分化和胚胎发生。Wnt信号通路中的障碍与病理条件下,尤其是癌症。通路可以被认为是一个有前途的战略和一些药物开发这个策略。天然营养食品复合只发现在不同的水果和坚果如葡萄、花生、开心果。化合物具有良好的生物和治疗活动,如抗氧化剂,抗炎、抗肿瘤、王亚南心血管,抗糖尿病的。目前的审查,我们将演示如何Res调节Wnt信号通路发挥药理作用。

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来源
《Journal of cellular physiology.》 |2020年第5期|4135-4145|共11页
作者
Milad Ashrafizadeh; Zahra Ahmadi; Tahereh FarkhondehSaeed Samarghian;
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作者单位

Department of Basic Science, University of Tabriz, Tabriz, Iran;

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正文语种英语
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resveratrol; Wnt Signaling Pathway; Wnt Signaling Pathway PIDcancer therapyCanonical Wnt Signaling PathwayNoncanonical Wnt Signaling PathwayNotch and Wnt Signaling PathwayPlants, Medicinal;

机译：白藜芦醇,Wnt信号途径;Wnt信号通路PIDcancer therapyCanonical Wnt信号PathwayNoncanonical Wnt信号PathwayNotch和Wnt信号PathwayPlants,药用;

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Resveratrol targeting the Wnt signaling pathway: A focus on therapeutic activities

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