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首页> 外文期刊>Journal of cellular physiology. >Developments in the study of gastrointestinal microbiome disorders affected by FGF19 in the occurrence and development of colorectal neoplasms
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Developments in the study of gastrointestinal microbiome disorders affected by FGF19 in the occurrence and development of colorectal neoplasms

机译：胃肠道的研究的发展肠道菌群失调FGF19的影响大肠癌的发生和发展肿瘤

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摘要

Colorectal neoplasms are a type of malignant digestive system tumor that has become the third-highest morbidity tumor in China and the fourth leading cause of cancer-related death worldwide. The role of the gastrointestinal (Gl) microbiome in bile acid metabolism, inflammation, and insulin resistance and its strong correlation with the occurrence and development of colorectal neoplasms have gradually led to it becoming a target area of tumor research. Fibroblast growth factor (FGF) 19 is a hormone that is secreted in mainly the ileum and can regulate bile acid biosynthesis, improve inflammation, and regulate insulin resistance. The relationship of the Gl microbiome, FGF19 and its carcinogenic activities in colorectal neoplasms enticed us to search for potential targets and research ideas for the clinical diagnosis and treatment of colorectal neoplasms.
机译：结直肠肿瘤是一种恶性的已成为消化系统肿瘤在中国,第三肿瘤发病率第四个癌症相关死亡的主要原因在全球范围内。微生物在胆汁酸代谢、炎症、和胰岛素抵抗及其强烈的相关性大肠癌的发生和发展肿瘤已经逐渐成为导致它肿瘤研究的目标区域。因子(FGF) 19是分泌的一种激素主要是回肠和可以调节胆汁酸生物合成,改善炎症和调节胰岛素抵抗。微生物,FGF19及其致癌的活动在结直肠肿瘤引诱我们去寻找潜在的目标和研究的想法大肠癌的临床诊断和治疗肿瘤。

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