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首页> 外文期刊>Journal of cellular physiology. >Autophagy and NLRP3 inflammasome crosstalk in neuroinflammation in aged bovine brains
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Autophagy and NLRP3 inflammasome crosstalk in neuroinflammation in aged bovine brains

机译：自噬和NLRP3 inflammasome相声神经炎症在岁牛的大脑

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摘要

NLRP3 inflammasome is a multiprotein complex that can sense several stimuli such as autophagy dysregulation and increased reactive oxygen species production stimulating inflammation by priming the maturation of proinflammatory cytokines interleukin-1β and interleukin-18 in their active form. In the aging brain, these cytokines can mediate the innate immunity response priming microglial activation. Here, we describe the results of immunohistochemical and molecular analysis carried out on bovine brains. Our results support the hypothesis that the age-related impairment in cellular housekeeping mechanisms and the increased oxidative stress can trigger the inflammatory danger sensor NLRP3. Moreover, according to the recent scientific literature, we demonstrate the presence of an age-related proinflammatory environment in aged brains consisting in an upregulation of interleukin-1β, an increased microglial activation and increased NLRP3 expression. Finally, we suggest that bovine may potentially be a pivotal animal model for brain aging studies.
机译：NLRP3 inflammasome multiprotein复杂可以感知等刺激自体吞噬失调,增加了活性氧物种生产刺激炎症启动促炎的成熟细胞因子β及interleukin-18他们的活性形式。先天免疫细胞因子可以调解响应启动小胶质激活。免疫组织化学和描述结果进行分子分析牛的大脑。我们的研究结果支持这一假设与年龄相关的损害细胞的管家机制和氧化压力的增加触发传感器NLRP3发炎的危险。此外,根据最近的科学文学,我们展示的存在与年龄相关的促炎的环境大脑的upregulation组成interleukin-1β,增加小胶质激活和增加NLRP3表达式。最后,我们表明,牛可能是一个关键的大脑衰老动物模型研究。

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