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首页> 外文期刊>Journal of cellular physiology. >The role of Hippo signaling pathway and mechanotransduction in tuning embryoid body formation and differentiation
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The role of Hippo signaling pathway and mechanotransduction in tuning embryoid body formation and differentiation

机译：河马和信号通路的作用转导在调优胚状体的身体形成和分化

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Embryoid bodies (EBs) are the three-dimensional aggregates of pluripotent stem cells that are used as a model system for the in vitro differentiation. EBs mimic the early stages of embryogenesis and are considered as a potential biomimetic body in tuning the stem cell fate. Although EBs have a spheroid shape, they are not formed accidentally by the agglomeration of cells; they are formed by the deliberate and programmed aggregation of stem cells in a complex topological and biophysical microstructure instead. EBs could be programmed to promisingly differentiate into the desired germ layers with specific cell lineages, in response to intra- and extra-biochemical and biomechanical signals. Hippo signaling and mechanotransduction are the key pathways in controlling the formation and differentiation of EBs. The activity of the Hippo pathway strongly relies on cell-cell junctions, cell polarity, cellular architecture, cellular metabolism, and mechanical cues in the surrounding microenvironment Although the Hippo pathway was initially thought to limit the size of the organ by inhibiting the proliferation and the promotion of apoptosis, the evidence suggests that this pathway even regulates stem cell self-renewal and differentiation. Considering the abovementioned explanations, the present study investigated the interplay of the Hippo signaling pathway, mechanotransduction, differentiation, and proliferation pathways to draw the molecular network involved in the control of EBs fate. In addition, this study highlighted several neglected critical parameters regarding EB formation, in the interplay with the Hippo core component involved in the promising differentiation.
机译：拟胚体(EBs)是三维的骨料的多能干细胞用作体外模型体系分化。胚胎发生和被认为是潜在的仿生机构优化干细胞的命运。尽管EBs球体形状,它们不是意外的聚集形成的细胞;编程复杂聚合的干细胞拓扑和生物物理微观结构代替。分化成所需的胚芽层特定的细胞谱系,在应对内部和extra-biochemical和生物力学信号。河马和转导信号在控制形成和关键途径EBs的分化。通路强烈依赖于信息连接,细胞极性,细胞结构,细胞新陈代谢,和机械的线索周围的微环境虽然河马通路最初认为限制大小的器官通过抑制增殖和促进细胞凋亡,证据显示甚至这个途径调节干细胞自我更新和分化。上述解释,目前的研究调查了河马信号的相互作用转导通路,分化,和增殖通路分子网络参与EBs命运的控制。此外,这项研究强调了几个关于海尔哥哥被忽视的重要参数形成,在河马的相互作用的核心组件参与这项承诺分化。

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