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首页> 外文期刊>Journal of cellular physiology. >The chromosome 19 microRNA cluster, regulated by promoter hypomethylation, is associated with tumour burden and poor prognosis in patients with hepatocellular carcinoma
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The chromosome 19 microRNA cluster, regulated by promoter hypomethylation, is associated with tumour burden and poor prognosis in patients with hepatocellular carcinoma

机译：19号染色体microRNA集群,由启动子hypomethylation联系在一起肿瘤患者的负担和不良预后肝细胞癌

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摘要

Hepatocellular carcinoma (HCC) is still one of the major malignant tumours with poor prognosis. The chromosome 19 microRNA cluster (C19MC) is the largest miRNA cluster, and its functions and regulatory mechanisms remain unclear in HCC. We extracted data from 373 HCC samples and 50 non-tumour samples from The Cancer Genome Atlas database. The differential expression levels and methylation levels of C19MC as well as the correlation between them were analysed. We evaluated the correlation between the expression levels of C19MC and the clinical features. We further performed prognostic analysis for C19MC and analysed the bioinformatic function. C19MC had upregulated expression levels and promoter hypomethylation in HCC. A significant negative correlation between the high expression and low methylation level of C19MC was obtained. In addition, the positive correlation between the expression levels of C19MC and the tumour grade, tumour stage and T-stage is shown. Three miRNAs (mir-512-1, mir-516a-l, mir-519a-2) were negatively associated with overall survival on the basis of the Kaplan-Meier analysis and the 3-miRNA signature was significant for the prognostic assessment of HCC. A bioinformatic enrichment analysis suggested that the target genes of the 3 miRNAs may be associated with mitogen-activated protein kinase pathways related to cancer invasion. In summary, our novel study demonstrated that the hypomethylation of promoters upregulates the expression levels of C19MC and that C19MC may represent a potential new candidate for the diagnosis and therapy of HCC.
机译：肝细胞癌(HCC)仍然是其中的一个主要恶性肿瘤预后差。19号染色体微集群(C19MC)是最大的microrna的集群,其功能和监管在肝癌机制尚不清楚。提取的数据从373年肝癌样本和50non-tumour样本癌症基因组图谱数据库。甲基化水平的C19MC以及他们之间的相关性进行分析。评价之间的关系表达式C19MC水平和临床特征。进一步为C19MC预后进行分析和分析了生物功能。水平调节表达启动子hypomethylation肝癌。高表达和低之间的相关性甲基化水平的C19MC。之间的正相关关系C19MC表达水平与肿瘤级别,肿瘤阶段和t台。(mir - 512 - 1, mir - 516 - a - l, mir - 519 - 2)消极与整体生存有关kaplan meier分析和的基础3-miRNA签名是重要的肝细胞癌的预后评估。富集分析建议的目标3 microrna基因可能是相关的增殖蛋白激酶通路相关癌症入侵。证明了hypomethylation启动子的表达水平上调C19MC C19MC可能代表一个潜在的新候选人的诊断和治疗HCC。

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