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首页> 外文期刊>Journal of cellular physiology. >Anti-inflammatory effect of octyl gallate in alveolar macrophages cells and mice with acute lung injury
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Anti-inflammatory effect of octyl gallate in alveolar macrophages cells and mice with acute lung injury

机译：没食子酸正辛酯的抗炎效果肺泡巨噬细胞细胞和小鼠急性肺损伤

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Acute lung injury (ALI) is an inflammatory process, and has high incidence and mortality. ALI and the acute respiratory distress syndrome are two common complications worldwide that result in acute lung failure, sepsis, and death. Pro-inflammatory substances, such as cytokines and chemokines, are responsible for activating the body's defense mechanisms and usually mediate inflammatory processes. Therefore, the research of substances that decrease the uncontrolled response of organism is seen as potential for patients with ALI. Octyl gallate (OG) is a phenolic compound with therapeutic actions namely antimicrobial, antiviral, and antifungal. In this study, we evaluated its action on lipopolysaccharide (LPS)-activated alveolar macrophages RAW 264.7 cells and ALI in male mice. Our results demonstrated protective effects of OG in alveolar macrophages activated with LPS and mice with ALI. The OG treatment significantly decreased the inflammatory markers in both studies in vitro and in vivo. The data suggested that OG can act as an anti-inflammatory agent for ALI.
机译：急性肺损伤(ALI)是一种炎症过程,具有较高的发病率和死亡率。阿里和急性呼吸窘迫综合征两种常见的并发症导致急性肺衰竭、败血症和死亡。炎性物质,如细胞因子和趋化因子激活负责通常人体的防御机制,调解炎症过程。减少不受控制的物质有机体的反应被视为潜力ALI患者。酚类化合物与治疗即行动抗菌、抗病毒和抗真菌。研究中,我们评估其行动脂多糖(LPS)激活肺泡264.7巨噬细胞原始细胞和阿里在雄性老鼠。我们的研究结果表明王噩的保护作用在肺泡巨噬细胞激活和有限合伙人老鼠与阿里。减少炎症标记物在两种研究在体外和体内。OG可以作为抗炎剂

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