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首页> 外文期刊>Journal of cellular physiology. >Ellagicacid protects ovariectomy-induced bone loss in mice by inhibiting osteoclast differentiation and bone resorption
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Ellagicacid protects ovariectomy-induced bone loss in mice by inhibiting osteoclast differentiation and bone resorption

机译：Ellagicacid保护ovariectomy-induced骨质流失在老鼠通过抑制破骨细胞分化和骨吸收

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摘要

Osteoporosis is a devastating disease that features reduced bone quantity and microstructure, which causes fragility fracture and increases mortality, especially in the aged population. Due to the long-term side-effects of current drugs for osteoporosis, it is of importance to find other safe and effective medications. Ellagic acid (EA) is a phenolic compound found in nut galls, plant extracts, and fruits, and exhibits antioxidant and antineoplastic effects. Here, we showed that EA attenuated the formation and function of osteoclast dose-dependently. The underlying mechanism was further discovered by western blot, immunofluorescence assay, and luciferase assay, which elucidated that EA suppressed osteoclastogenesis and bone resorption mainly through attenuating receptor activator of nuclear factor-KB (NF-KB) ligand-induced NF-kB activation and extracellular signal-regulated kinase signaling pathways, accompanied by decreased protein expression of nuclear factor of activated T-cells calcineurin-dependent 1 and c-Fos. Moreover, EA inhibits osteoclast marker genes expression including Dc-stamp, Ctsk, Atp6v0d2, and Acp5. Intriguingly, we also found that EA treatment could significantly protect ovariectomy-induced bone loss in vivo. Conclusively, this study suggested that EA might have the therapeutic potentiality for preventing or treating osteoporosis.
机译：骨质疏松症是一种毁灭性的疾病减少骨数量和特性微观结构,导致脆性断裂和增加死亡率,尤其是老年人人口。目前骨质疏松药物,来寻找其他的安全有效的重要性的药物。化合物中发现螺母五倍子、植物提取物和抗氧化和水果和展品抗肿瘤的效果。减毒的形成和功能破骨细胞存在剂量依赖的相关性。机制是进一步发现的免疫印迹,免疫荧光检测,荧光素酶测定这阐明EA镇压主要osteoclastogenesis和骨吸收通过衰减的核受体激活factor-KB (NF-KB) ligand-induced NF-KB激活和细胞外signal-regulated激酶信号通路,伴随着降低了蛋白表达的核转录因子激活t细胞calcineurin-dependent 1和c-Fos。此外,EA抑制破骨细胞标记基因表达式包括Dc-stamp Ctsk Atp6v0d2,和Acp5。治疗可以显著保护ovariectomy-induced骨质流失体内。最后,本研究建议EA对防止有治疗潜力吗或治疗骨质疏松症。

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