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首页> 外文期刊>BMJ: British medical journal >Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and mela-analyses
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Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and mela-analyses

机译：增加钾的摄入量的影响心血管危险因素和疾病:系统回顾和mela-analyses

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STUDY QUESTION What are the effects of increased potassium intake on blood pressure, mortality and morbidity from cardiovascular diseases, and incidence of adverse effects in apparently healthy adults and children without acute illness or impaired renal handling of potassium? SUMMARY ANSWER High quality evidence shows that increased potassium intake reduces blood pressure in adults with hypertension and has no adverse effect on blood lipid concentrations, catecholamine concentrations, or renal function; higher potassium intake is also associated with a 24% reduced risk of stroke (moderate and low quality evidence); evidence in children is sparse but also suggests a benefit on blood pressure with higher potassium intake. WHAT IS KNOWN AND WHATTHIS PAPER ADDS Low potassium intake has been associated with high blood pressure and risk of some cardiovascular diseases, but the evidence is not entirely consistent. This review provides the most comprehensive and up to date synthesis of literature on potassium intake and health outcomes and concludes that increased potassium intake is beneficial for reducing blood pressure and riskof stroke. Selection criteria for studies We systematically searched the Cochrane Central Register of Controlled Trials, Medline, Embase, the World Health Organization International Clinical Trials Registry Plat-form,the Latin American and Caribbean Health Science Literature Database, and the reference lists of previous reviews for randomised controlled trials and prospective cohort studies investigating potassium intake in apparently healthy adults and children without acute illness or renal impairment that might compromise handling of potassium. Primary outcome(s) The primary outcomes, as prioritised by the WHO Nutrition Expert Advisory Group, were blood pressure, blood lipid concentrations, catecholamine concentrations, and renal function in adults and children and all cause mortality, cardiovascular disease, stroke, and coronary heart disease in adults. Main results and role of chance Twenty two randomised controlled trials (including 1606 participants) reporting blood pressure, blood lipids, catecholamine concentrations, or renal function and 11 cohort studies (127 038 participants) reporting all cause mortality, cardiovascular disease, stroke, or coronary heart disease contributed to the meta-analyses in adults.
机译：研究问题是什么增加的影响钾摄入量对血压、死亡率和从心血管疾病发病率,明显的副作用发生率健康成人和儿童没有急性疾病钾或受损的肾脏处理?回答高质量证据显示增加钾摄入量降低血压在成人与高血压和没有不良影响血脂浓度,儿茶酚胺的浓度,或肾功能;钾的摄入也是24%减少中风的风险(中度和低质量证据);还建议对血压的一个好处高钾的摄入量。WHATTHIS论文增加了低钾的摄入量与高血压和风险相关联一些心血管疾病,但证据不是完全一致的。最全面的和最新的合成文学对钾的摄入和健康结果和得出结论,增加钾摄入有利于降低血压中风和危险性。我们系统地搜索Cochrane中央注册的对照试验,Medline和Embase,世界卫生组织国际临床试验注册中心高台,拉丁语美国和加勒比健康科学文献数据库,和以前的参考书目中为随机对照试验和评论前瞻性群组研究调查在看似健康的成年人和钾摄入量孩子没有急性疾病和肾障碍可能妥协处理钾。结果,作为优先考虑的营养专家咨询小组,血压,血脂质浓度,儿茶酚胺的浓度,并在成人和肾功能孩子和所有原因的死亡率、心血管疾病疾病、中风和冠心病成年人。两个随机对照试验(包括1606参与者)报道血压、血脂类、儿茶酚胺浓度或肾函数和11个队列研究(127 038参与者)报告所有原因的死亡率,心血管疾病、中风、冠心病疾病导致的荟萃分析成年人。

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