• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Aerospace medicine and human performance. >Revisions to Limits for Methanol in the Air of Spacecraft
【24h】

Revisions to Limits for Methanol in the Air of Spacecraft

机译：修正为空气中甲醇的限制宇宙飞船

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The previous Spacecraft Maximal Allowable Concentrations (SMACs) for methanol were established by characterizing minor effects upon cognitive functions as a no-observable adverse effects level (NOAEL). However, an increasing awareness of the risk posed by Space-Associated Neuro-ocular Syndrome (SANS) has caused NASA Toxicology to reexamine SMACs for methanol because exposure to it can also adversely affect ocular health. An updated review of the literature indicates that no adjustments to the SMACs due to SANS complications were required, while confirming that effects upon the central nervous system remain the appropriate basis for the SMACs for methanol. Our review, however, identified several issues that provide justification for modest SMAC reductions. It has recently been recognized that inhaled methanol may reach the brain via the olfactory system and be absorbed there into the highly toxic metabolite formaldehyde. A benchmark dose (BM) for an extra risk of 10%, derived from an analysis of the incidences of neurological lesions in monkeys chronically exposed to methanol, is an order of magnitude less than the Environmental Protection Agency's (EPA's) reference concentration for chronic inhalation of methanol. Reports calling attention to the relative insensitivity of traditional methods of assessing cognitive function erode confidence that adverse effects at the concentration reported as a NOAEL would have been recognizable. Therefore, an additional modest safety factor of three is applied to SMACs for methanol.
机译：之前的飞船最大容许浓度(SMACs)甲醇建立了描述小影响作为一个没有观察不良认知功能影响程度(科学)。空间构成的风险的意识NASA Neuro-ocular综合征(SANS)引起毒理学重新审视SMACs甲醇因为暴露在它也可以产生负面影响眼部健康。文献表明,没有调整SMACs由于无并发症是必需的,同时确认影响中央神经系统保持适当的依据SMACs甲醇。确认提供的几个问题适度的SMAC降低的理由。最近认识到吸入甲醇通过嗅觉系统和可能达到大脑吗被吸收进了剧毒代谢产物甲醛。一个额外的风险为10%,来自一个分析神经的发生率长期暴露于病变猴子甲醇,比少一个数量级环境保护署(EPA)参考浓度长期吸入甲醇。传统的方法的相对不敏感评估认知功能损害的信心不良反应的浓度报告为科学可辨认的。因此,一个额外的温和的安全系数三个应用于SMACs甲醇。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号