Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder

Nazree Nur Elia; Mohamed Zahurin; Reynolds Gavin P.Zain Shamsul MohdMasiran RuzianaSidi HattaChong Lu AnnHway Anne YeeAdlan Aida SyarinazZainal Nor Zuraida

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Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder

机译：脑源性神经营养因子的协会缬氨酸与性蛋氨酸多态性功能障碍后选择性5 -羟色胺再摄取抑制剂治疗的女性患者重度抑郁症患者

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IntroductionThe occurrence of female sexual dysfunction (FSD) in patients with major depressive disorder (MDD) receiving selective serotonin reuptake inhibitors (SSRIs) treatment gives negative impacts on patients' quality of life and causes treatment discontinuation. We aimed to investigate whether genetic polymorphism of identified candidate gene is associated with FSD in our study population.

机译：IntroductionThe女性性的发生障碍(FSD)患者的专业抑郁症(MDD)接收选择性5 -羟色胺再摄取抑制剂(SSRIs)治疗给出了负面影响病人的质量生活和事业治疗停药。目的调查是否遗传多态性确定候选基因的关联在我们的研究人群女性性功能障碍。

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来源
《Asia-Pacific psychiatry :》 |2016年第4期|260-268|共9页
作者
Nazree Nur Elia; Mohamed Zahurin; Reynolds Gavin P.Zain Shamsul MohdMasiran RuzianaSidi HattaChong Lu AnnHway Anne YeeAdlan Aida SyarinazZainal Nor Zuraida;
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作者单位

Univ Kebangsaan Malaysia, Dept Psychiat, Med Ctr, Kuala Lumpur, Malaysia;

Sheffield Hallam Univ, Biomed Res Ctr, Sheffield, S Yorkshire, England;

Univ Malaya, Dept Psychol Med, Fac Med, Kuala Lumpur, MalaysiaUniv Malaya, Pharmacogen Lab, Dept Pharmacol, Fac Med, Kuala Lumpur, Malaysia;

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正文语种英语
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关键词
female sexual dysfunction; Pharmacogenetics; PharmacogenomicsSerotonin Uptake InhibitorsMajor Depressive DisorderBrain-Derived Neurotrophic FactorEndogenous DepressionSexual Dysfunction;

机译：女性性功能障碍、药物基因学、医药;

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Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder

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