Principal component analysis is limited to low-resolution analysis in cryoEM

Carlos Oscar S. Sorzano; Jose Maria Carazo

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Principal component analysis is limited to low-resolution analysis in cryoEM

机译：主成分分析是有限的低分辨率分析cryoEM

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摘要

Principal component analysis (PCA) has been widely proposed to analyze flexibility and heterogeneity in cryo-electron microscopy (cryoEM). In this paper, it is argued that (i) PCA is an excellent technique to describe continuous flexibility at low resolution (but not so much at high resolution) and (ii) PCA components should be analyzed in a concerted manner (and not independently).

机译：主成分分析(PCA)已被广泛提出了分析灵活性和异质性在低温电子显微镜(cryoEM)。纸,是认为(i) PCA是一个很好的技术描述连续的灵活性低分辨率(但不是很高分辨率)和(2)主成分分析组件以协调一致的方式(而不是分析独立)。

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《Acta crystallographica. Section D, Structural biology》 |2021年第6期|835-839|共5页
作者
Carlos Oscar S. Sorzano; Jose Maria Carazo;
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作者单位

National Center of Biotechnology (CSIC), Darwin 3, Campus Universidad Autonoma de Madrid;

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正文语种英语
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关键词
Protein Structure; Passive Cutaneous Anaphylaxis; Flexibilityprincipal components analysisthree-dimensional displayscomponent analysisMultiresolution analysisCryoelectron MicroscopyImage processing;

机译：蛋白质结构;被动皮肤速发型过敏反应;Flexibilityprincipal组件analysisthree-dimensional displayscomponentanalysisMultiresolution analysisCryoelectronMicroscopyImage处理;

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Principal component analysis is limited to low-resolution analysis in cryoEM

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