Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1

Jakub Luptak; Michal Bista; David FisherLiz FlavellNing GaoKateWicksonSteven L. KazmirskiTina HowardPhilip B. RawlinsDavidHargreaves

首页> 外文期刊>Acta crystallographica. Section D, Structural biology. >Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1

【24h】

Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1

机译：抗体片断结构支持癌症药物运动的目标mcl1

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Apoptosis is a crucial process by which multicellular organisms control tissuegrowth, removal and inflammation. Disruption of the normal apoptotic functionis often observed in cancer, where cell death is avoided by the overexpression ofanti-apoptotic proteins of the Bcl-2 (B-cell lymphoma 2) family, including Mcl-1(myeloid cell leukaemia 1). This makes Mcl-1 a potential target for drug therapy,through which normal apoptosis may be restored by inhibiting the protectivefunction of Mcl-1. Here, the discovery and biophysical properties of an anti-Mcl-1 antibody fragment are described and the utility of both the scFv and Fabare demonstrated in generating an Mcl-1 crystal system amenable to iterativestructure-guided drug design.

机译：细胞凋亡是一个至关重要的过程多细胞生物控制tissuegrowth,删除和炎症。正常凋亡functionis经常观察到癌症,避免细胞死亡的超表达ofanti-apoptotic蛋白质的bcl - 2 (b细胞淋巴瘤2)的家庭,包括mcl1(髓细胞白血病1)。这使得mcl1一个潜在的药物治疗的目标,通过它正常细胞凋亡可能是通过抑制恢复mcl1的protectivefunction。发现和生物物理属性的anti-Mcl-1抗体片段和描述scFv和Fabare的效用在生成一个mcl1晶体系统适合iterativestructure-guided药物设计。

著录项

来源
《Acta crystallographica. Section D, Structural biology.》 |2019年第11期|1003-1014|共12页
作者
Jakub Luptak; Michal Bista; David FisherLiz FlavellNing GaoKateWicksonSteven L. KazmirskiTina HowardPhilip B. RawlinsDavidHargreaves;
展开▼
作者单位

Discovery Sciences, R&D Biopharmaceuticals, AstraZeneca, Cambridge CB4 0WG, England;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
MCL1 gene; Immunoglobulin Fab Fragments; Drug Designcrystal systemsImmunoglobulin Fragments;

机译：MCL1基因;免疫球蛋白Fab片段;药物Designcrystal systemsImmunoglobulin片段;

相似文献

外文文献
中文文献
专利

1. Optimized functional and structural design of dual-target LMRAP, a bifunctional fusion protein with a 25-amino-acid antitumor peptide and GnRH Fc fragment [J] . Meng Li, Hanmei Xu, Junzhi Wang 药学学报（英文版） . 2020,第002期
2. Optimized functional and structural design of dual-target LMRAP,a bifunctional fusion protein with a 25-amino-acid antitumor peptide and GnRH Fc fragment [J] . Meng Li, Hanmei Xu, Junzhi Wang 药学学报：英文版 . 2020,第002期
3. In properly selected patients with differentiated thyroid cancer, antithyroglobulin antibodies decline after thyroidectomy and their sole presence should not be an indication for radioiodine ablation [J] . Felipe Zavala Luis, Ines Barra Maria, Olmos Roberto, Journal of neurosurgical sciences . 2019,第3期

机译：In properly selected patients with differentiated thyroid cancer, antithyroglobulin antibodies decline after thyroidectomy and their sole presence should not be an indication for radioiodine ablation
4. Refined construction of antibody-targeted nanoparticles leads to superior antigen binding and enhanced delivery of an entrapped payload to pancreatic cancer cells [J] . Greene Michelle K., Nogueira Joao C. F., Tracey Shannon R.Richards Daniel A.McDaid William J.Burrows James F.Campbell KatrinaLongley Daniel B.Chudasama VijayScott Christopher J. Nanoscale . 2020,第21期

机译：精制antibody-targeted建设纳米颗粒导致优越的抗原结合和增强交付的裹入载荷胰腺癌细胞
5. Antibody-targeting of ultra-small nanoparticles enhances imaging sensitivity and enables longitudinal tracking of multiple myeloma [J] . Alexandre Detappe, Mairead Reidy, Yingjie Yu Nanoscale . 2019,第43期

机译：Antibody-targeting超薄纳米粒子的增强成像灵敏度和支持多发性骨髓瘤的纵向跟踪
6. A Structural Reliability Analysis Method Based on Target-oriented Krill Herd Algorithm [C] . Lixiang Cheng, Yan-gang Zhao 日本建築学会大会;日本建築学会 . -1

机译：A Structural Reliability Analysis Method Based on Target-oriented Krill Herd Algorithm
7. The ‘Be Cancer Alert Campaign’: protocol to evaluate a mass media campaign to raise awareness about breast and colorectal cancer in Malaysia [O] . Désirée Schliemann, Michael Donnelly, Maznah Dahlui, 2018

机译：Be Cancer Alert Campaign（Be癌症警报运动）：评估大众媒体运动以提高人们对马来西亚乳腺癌和结直肠癌认识的方案
8. https://researchopenworld.com/development-of-synthetic-cell-differentiation-agent-formulations-for-the-prevention-and-therapy-of-cancer-via-targeting-of-cancer-stem-cells/# [O] . 2019

机译：https://researchopenworld.com/development-of-synthetic-cell-differentiation-agent-formulations-for-the-prevention-and-therapy-of-cancer-via-targeting-of-cancer-stem-cells/#

Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1

摘要

著录项

相似文献

相关主题

期刊订阅