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首页> 外文期刊>Acta crystallographica. Section D, Structural biology. >Radiation damage in protein crystallography at X‐ray free‐electron lasers
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Radiation damage in protein crystallography at X‐ray free‐electron lasers

机译：辐射损伤的蛋白质晶体学X射线应承担的自由电子激光器

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摘要

Radiation damage is still the most limiting factor in obtaining high‐resolution structures of macromolecules in crystallographic experiments at synchrotrons. With the advent of X‐ray free‐electron lasers (XFELs) that produce ultrashort and highly intense X‐ray pulses, it became possible to outrun most of the radiation‐damage processes occurring in the sample during exposure to XFEL radiation. Although this is generally the case, several experimental and theoretical studies have indicated that structures from XFELs may not always be radiation‐damage free. This is especially true when higher intensity pulses are used and protein molecules that contain heavy elements in their structures are studied. Here, the radiation‐damage mechanisms that occur in samples exposed to XFEL pulses are summarized, results that show indications of radiation damage are reviewed and methods that can partially overcome it are discussed.
机译：辐射损伤仍然是最限制因素在获得高分辨率的结构大分子结晶实验同步加速器。自由电子激光(XFELs)生产超短,高度强烈的X射线脉冲,它超过大多数成为可能的辐射损伤过程发生在暴露于XFEL辐射样品。虽然这是一般的情况下,几个实验和理论研究从XFELs并不表明结构总是辐射损害应承担的自由。特别是在高强度脉冲使用和蛋白质分子含有重元素的结构进行了研究。辐射损伤发生的机制样品接触XFEL脉冲进行了总结,结果显示辐射损伤的迹象综述了和方法可以部分讨论了克服它。

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