Single-molecule DNA mapping for pathogen detection

Robert H. Meltzer

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Single-molecule DNA mapping for pathogen detection

机译：单分子DNA映射病原体检测

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Detection and identification of Clostridium botulinum is of particular concern due to the extreme pathogenicity of its toxin. Herein, we review the potential applicability of two novel technologies for detection of Clostridium botulinum and botulinumtoxin. Genome sequence scanning (GSS) provides strain-specific bacterial identification from complex bacterial mixtures by detecting the distribution of fluorescent sequence-specific probes along long linearised DNA fragments. Digital DNA (DD) utilises long fluorescent labelled DNA molecules as binary labelled tags to facilitate multiplex antigen detection. Both technologies share automated sample preparation and detection instrumentation. GSS and DD have particular applicability for botulinum detectionand identification, but have broad-reaching applicability to food safety testing and clinical diagnostics in general.

机译：梭状芽胞杆菌的检测和识别由于肉毒杆菌尤其关注极端的致病性的毒素。审查的潜在适用性两本小说梭状芽胞杆菌的检测技术肉毒杆菌和botulinumtoxin。扫描(GSS)提供毒株特异性细菌识别从复杂细菌混合物检测荧光的分布sequence-specific探测器沿长使直线化DNA片段。荧光标记的DNA分子作为二进制贴上标签来促进复合抗原检测。样品制备和检测仪器。GSS和弟弟有特殊的适用性肉毒杆菌detectionand识别,但是食品安全具有广泛深远影响的适用性测试和临床诊断。

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《The Botulinum Journal》 |2012年第2期|159-163|共5页
作者
Robert H. Meltzer;
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作者单位

Pathogenetix,12 Gill Street, Suite 3150,Woburn, MA 01801, USA;

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原文格式 PDF
正文语种英语
中图分类微生物学;
关键词
antigen test; DNA; TechnologySpecimen preparationClostridium botulinumgenetic mappingsingle molecule;

机译：preparationClostridium botulinumgeneticmappingsingle分子;

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Single-molecule DNA mapping for pathogen detection

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