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首页> 外文期刊>Acta crystallographica. Section D, Structural biology. >The importance of the helical structure of a MamC‐derived magnetite‐interacting peptide for its function in magnetite formation
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The importance of the helical structure of a MamC‐derived magnetite‐interacting peptide for its function in magnetite formation

机译：的螺旋结构的重要性MamC量推导出磁铁矿量相互作用的肽其功能在磁铁矿形成

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摘要

Biomineralization is the process of mineral formation by organisms and involves the uptake of ions from the environment in order to produce minerals, with the process generally being mediated by proteins. Most proteins that are involved in mineral interactions are predicted to contain disordered regions containing large numbers of negatively charged amino acids. Magnetotactic bacteria, which are used as a model system for iron biomineralization, are Gram‐negative bacteria that can navigate through geomagnetic fields using a specific organelle, the magnetosome. Each organelle comprises a membrane‐enveloped magnetic nanoparticle, magnetite, the formation of which is controlled by a specific set of proteins. One of the most abundant of these proteins is MamC, a small magnetosome‐associated integral membrane protein that contains two transmembrane α‐helices connected by an ～21‐amino‐acid peptide. In vitro studies of this MamC peptide showed that it forms a helical structure that can interact with the magnetite surface and affect the size and shape of the growing crystal. Our results show that a disordered structure of the MamC magnetite‐interacting component (MamC‐MIC) abolishes its interaction with magnetite particles. Moreover, the size and shape of magnetite crystals grown in in vitro magnetite‐precipitation experiments in the presence of this disordered peptide were different from the traits of crystals grown in the presence of other peptides or in the presence of the helical MIC. It is suggested that the helical structure of the MamC‐MIC is important for its function during magnetite formation.
机译：生物矿化是矿物的过程形成的生物和涉及到的吸收为了产生离子的环境矿物质、一般过程由蛋白质。参与矿物相互作用预测包含无序区域包含大带负电荷的氨基酸的数量。趋磁细菌,这是作为一个模型铁生物矿化系统革兰氏阴性细菌应承担的导航地磁字段使用特定的细胞器,磁小体。膜包围应承担的磁性纳米颗粒,磁铁矿,控制的形成由一组特定的蛋白质。这些蛋白质的丰富是MamC,一个小磁小体膜蛋白相关积分包含两个跨膜α螺旋连接由一个~ 21氨基酸肽。这MamC肽的研究显示,它形式一个螺旋结构,可以与之交互磁铁矿表面和影响大小和形状不断增长的晶体。MamC的无序结构磁铁矿量交互组件(MamC检测麦克风)消除与磁铁矿的交互粒子。磁铁矿晶体生长在体外磁铁矿沉淀实验这个无序肽的存在不同于晶体生长的特征其他肽或存在的存在螺旋的麦克风。MamC麦克风应承担的螺旋结构是很重要的其功能在磁铁矿形成。

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