Cryo‐electron microscopy of chromatin biology

Wilson Marcus D.; Costa Alessandro

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Cryo‐electron microscopy of chromatin biology

机译：低温电子显微镜染色质生物学

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摘要

The basic unit of chromatin, the nucleosome core particle (NCP), controls how DNA in eukaryotic cells is compacted, replicated and read. Since its discovery, biochemists have sought to understand how this protein–DNA complex can help to control so many diverse tasks. Recent electron‐microscopy (EM) studies on NCP‐containing assemblies have helped to describe important chromatin transactions at a molecular level. With the implementation of recent technical advances in single‐particle EM, our understanding of how nucleosomes are recognized and read looks to take a leap forward. In this review, the authors highlight recent advances in the architectural understanding of chromatin biology elucidated by EM.

机译：染色质的基本单位,核小体核心粒子(NCP),控制如何在真核生物的DNA细胞是压实,复制和阅读。它的发现,生物化学家试图可以帮助理解这个protein-DNA复杂控制很多不同的任务。电子显微镜(EM)的研究大会党包含组件帮助来描述重要的染色质事务在一个分子的水平。技术进步在单粒子EM应承担的,我们的了解如何识别核小体和阅读看起来飞跃。回顾,作者强调最近的进展建筑对染色质的理解通过EM生物阐明。

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来源
《Acta crystallographica. Section D, Structural biology.》 |2017年第6期|541-548|共8页
作者
Wilson Marcus D.; Costa Alessandro;
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作者单位

Macromolecular Machines Laboratory, The Francis Crick Institute, 1 Midland Road, LondonNW1 1AT, UK;

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原文格式 PDF
正文语种英语
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关键词
Eukaryotic Cells; histone code; ChromatinNucleosomesIntegrasesBiological Science Disciplines;

机译：真核细胞;组蛋白代码;ChromatinNucleosomesIntegrasesBiological科学学科;

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Cryo‐electron microscopy of chromatin biology

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