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首页> 外文期刊>Acta crystallographica. Section D, Structural biology. >Molecular architecture of the nucleoprotein C-terminal domain from the Ebola and Marburg viruses
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Molecular architecture of the nucleoprotein C-terminal domain from the Ebola and Marburg viruses

机译：核蛋白质的分子结构c端域埃博拉和马尔堡病毒

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摘要

The Filoviridae Filoviridae family of negative-sense, single-stranded RNA (ssRNA) viruses is comprised of two species ofMarburgvirus Marburgvirus (MARV and RAVV) and five species ofEbolavirus Ebolavirus,i.e. i.e. Zaire (EBOV), Reston (RESTV), Sudan (SUDV), Tai Forest (TAFV) and Bundibugyo (BDBV). In each of these viruses the ssRNA encodes seven distinct proteins. One of them, the nucleoprotein (NP), is the most abundant viral protein in the infected cell and within the viral nucleocapsid. It is tightly associated with the viral RNA in the nucleocapsid, and during the lifecycle of the virus is essential for transcription, RNA replication, genome packaging and nucleocapsid assembly prior to membrane encapsulation. The structure of the unique C-terminal globular domain of the NP from EBOV has recently been determined and shown to be structurally unrelated to any other known protein [Dziubaskaet al. et al. (2014),Acta Cryst Acta Cryst. D70 70, 2420-2429]. In this paper, a study of the C-terminal domains from the NP from the remaining four species ofEbolavirus Ebolavirus, as well as from the MARV strain ofMarburgvirus Marburgvirus, is reported. As expected, the crystal structures of the BDBV and TAFV proteins show high structural similarity to that from EBOV, while the MARV protein behaves like a molten globule with a core residual structure that is significantly different from that of the EBOV protein.
机译：丝状丝状的家庭消极意义上讲,单链RNA (ssRNA)病毒是由两个物种ofMarburgvirus Marburgvirus (50 / and RAVV) and5种ofEbolavirus Ebolavirus,即。森林(TAFV)和本迪布焦(BDBV)。这些病毒ssRNA编码七截然不同蛋白质。最丰富的病毒蛋白在感染细胞内的病毒核衣壳。与病毒RNA在紧密相关核衣壳,在生命周期的转录病毒至关重要,RNA基因组复制、包装和核衣壳装配前膜封装。独特的c端球状结构域的NP EBOV最近确定和结构无关任何其他已知的蛋白质(Dziubaskaet人等al。(2014),《结晶学报。2420 - 2429年)。从NP剩下的c端域四种ofEbolavirus Ebolavirus以及从MARV应变ofMarburgvirus Marburgvirus,据报道。BDBV和TAFV蛋白质高从EBOV结构相似,而麦夫蛋白像一个熔融球状体核心残余结构显著不同于EBOV蛋白质。

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