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首页> 外文期刊>Acta crystallographica. Section D, Structural biology. >Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus pneumoniae complex
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Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus pneumoniae complex

机译：quinolone-stabilized劈理的结构复杂的拓扑异构酶IV克雷伯氏菌肺炎和比较相关肺炎链球菌复杂

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摘要

Klebsiella pneumoniae is a Gram-negative bacterium that is responsible for a range of common infections, including pulmonary pneumonia, bloodstream infections and meningitis. Certain strains of Klebsiella have become highly resistant to antibiotics. Despite the vast amount of research carried out on this class of bacteria, the molecular structure of its topoisomerase IV, a type II topoisomerase essential for catalysing chromosomal segregation, had remained unknown. In this paper, the structure of its DNA-cleavage complex is reported at 3.35 angstrom resolution. The complex is comprised of ParC breakage-reunion and ParE TOPRIM domains of K. pneumoniae topoisomerase IV with DNA stabilized by levofloxacin, a broad-spectrum fluoroquinolone antimicrobial agent. This complex is compared with a similar complex from Streptococcus pneumoniae, which has recently been solved.
机译：肺炎克雷伯菌是一种革兰氏阴性细菌负责各种常见感染,包括肺肺炎,血液感染和脑膜炎。克雷伯氏菌菌株已成为高度耐抗生素。这类的研究细菌,它的分子结构拓扑异构酶IV, II型拓扑异构酶必不可少的促进染色体隔离一直不明。其DNA-cleavage结构复杂的报告为3.35埃分辨率。由帕洛阿尔托研究中心breakage-reunion和削减TOPRIM域的k .肺炎拓扑异构酶IV左氧氟沙星与DNA稳定的广谱氟喹诺酮类抗菌药物代理。肺炎链球菌的复杂最近被解决。

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