Anti‐CRISPR proteins: Counterattack of phages on bacterial defense (CRISPR/Cas) system

Chaudhary Kulbhushan; Chattopadhyay Anirudha; Pratap Dharmendra

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Anti‐CRISPR proteins: Counterattack of phages on bacterial defense (CRISPR/Cas) system

机译：反CRISPR应承担的蛋白质:噬菌体的反击细菌的防御(CRISPR / Cas)系统

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Since the dawn of life there is a never ending strife between bacteria and phages. Both are perpetually changing their strategies to take over each other. CRISPR/Cas is the most widespread defense system used by bacteria against mobile genetic elements (MGEs) such as phages, cojugative palsmids, transoposons, and pathogenicity islands. This system utilizes small guide RNA molecules to protect against phages infection and invasion by MGEs. Phages circumvent to these antiviral barriers by point mutation in PAM (protospacer‐adjacent motif) sequence, genome rearrangements and by using anti‐CRISPR proteins.

机译：自从生命永无止境细菌和噬菌体之间的冲突。永远改变他们的策略在对方。普遍的防御系统所使用的细菌针对移动遗传元素(mg)等噬菌体,cojugative palsmids transoposons,致病性的岛屿。指导RNA分子预防噬菌体由mg感染和入侵。这些抗病毒壁垒的点突变PAM (protospacer相邻应承担的主题)序列,基因组重组和通过使用反CRISPR应承担的蛋白质。

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来源
《Journal of Cellular Physiology》 |2018年第1期|57-59|共3页
作者
Chaudhary Kulbhushan; Chattopadhyay Anirudha; Pratap Dharmendra;
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作者单位

Department of Plant PathologyS.D. Agricultural UniversityS.K. Nagar,Gujrat,India;

Department of Genetics and Plant BreedingChaudhary Charan Singh UniversityMeerut,Uttar Pradesh,India;

Division of Plant PathologyIndian Agricultural Research InstituteNew Delhi,India;

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正文语种英语
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关键词
Bacteriophages; Pathogenicity Islands; Defense systemsbacteriaPoint Mutation;

机译：噬菌体,致病性岛;防御systemsbacteriaPoint突变;

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Anti‐CRISPR proteins: Counterattack of phages on bacterial defense (CRISPR/Cas) system

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