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首页> 外文期刊>Journal of Cellular Physiology >Fibroblast dynamics as an in vitro screening platform for anti‐fibrotic drugs in primary myelofibrosis
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Fibroblast dynamics as an in vitro screening platform for anti‐fibrotic drugs in primary myelofibrosis

机译：纤维母细胞动力学作为体外筛选抗纤维化药物应承担的主要平台骨髓纤维化

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Although the cause for bone marrow fibrosis in patients with myelofibrosis remains controversial, it has been hypothesized that it is caused by extensive fibroblast proliferation under the influence of cytokines generated by the malignant megakaryocytes. Moreover, there is no known drug therapy which could reverse the process. We studied the fibroblasts in a novel system using the hanging drop method, evaluated whether the fibroblasts obtain from patients are part of the malignant clone of not and, using this system, we screen a large library of FDA‐approved drugs to identify potential drugs candidates that might be useful in the treatment of this disease, specifically which would inhibit fibroblast proliferation and the development of bone marrow fibrosis. We have found that the BM fibroblasts are not part of the malignant clone, as previously suspected and two immunosuppressive medications—cyclosporine and mycophenolate mophetil, as most potent suppressors of the fibroblast collagen production thus potentially inhibitors of bone marrow fibrosis production in myelofibrosis.
机译：尽管骨髓纤维化的原因骨髓纤维化患者仍有争议的,它被假定是由大量的成纤维细胞增殖吗细胞因子的影响下产生的恶性巨核细胞。已知的药物治疗可以逆转的过程。系统使用悬滴法,评估是否从患者的成纤维细胞获得恶性克隆的一部分不是,使用这个系统,我们屏幕上一个很大的图书馆FDA批准的药物来识别潜在的药物候选人可能有用的治疗这种疾病,特别是抑制成纤维细胞增殖和的发展骨髓纤维化。成纤维细胞不属于恶性克隆,正如前面怀疑和两个免疫抑制medications-cyclosporine和霉酚酸mophetil最有效的抑制的所以可能会成纤维细胞胶原蛋白生产骨髓纤维化生产的抑制剂骨髓纤维化。

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