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首页> 外文期刊>Journal of Cellular Physiology >Curcumin as a potential candidate for treating hyperlipidemia: A review of cellular and metabolic mechanisms
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Curcumin as a potential candidate for treating hyperlipidemia: A review of cellular and metabolic mechanisms

机译：姜黄素治疗作为一个潜在的候选人高脂血症:细胞和审查代谢机制

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Curcumin is an herbal polyphenol extensively investigated for antioxidant, anti‐inflammatory, and hypolipidaemic properties. In the present review, the efficacy of curcumin for improving a plasma lipid profile has been evaluated and compared with statins, a well‐known class of medicines for treating hypercholesterolemia and hyperlipidaemia. Curcumin is presumably most effective in reducing triglyceride (TG), while statins are most efficient in lowering low‐density lipoproteins‐cholesterol (LDL‐C). Additionally, various molecular and metabolic mediators of cholesterol and plasma lipid homeostasis are discussed in relation to how they are modulated by curcumin or statins. Overall, curcumin influences the same mediators of plasma lipid alteration as statins do. Almost all the pathways through which cholesterol trafficking takes place are affected by these agents. These include gastrointestinal absorption of dietary cholesterol, hepatocellular removal of plasma cholesterol, the mediators of reverse cholesterol transport, and removal of cholesterol from peripheral tissues. Moreover, the reactive oxygen species (ROS) scavenging potential of curcumin limits the risk of lipid peroxidation that triggers inflammatory responses causing cardiovascular diseases (CVD) and atherosclerosis. Taken together, curcumin could be used as a safe and well‐tolerated adjunct to statins to control hyperlipidaemia more effectively than statins alone.
机译：姜黄素是一种植物多酚广泛研究抗氧化,抗高炎症和hypolipidaemic属性。审查,为改善姜黄素的功效等离子体已经评估和血脂与他汀类药物相比,一个好已知的一类药物用于治疗高胆固醇血症和hyperlipidaemia。有效地降低甘油三酯(TG),他汀类药物是最有效的降低量低密度脂蛋白胆固醇(LDL C)应承担的。此外,各种分子和代谢介质的胆固醇和血脂体内平衡将与他们讨论是通过控制调节姜黄素或他汀类药物。姜黄素影响相同的等离子体介质脂质改变,他汀类药物。胆固醇走私通道发生这些代理。包括胃肠道吸收的膳食胆固醇,肝细胞的等离子体胆固醇、介质反向胆固醇运输、胆固醇和删除外围组织。姜黄素的物种(ROS)清除潜力限制了脂质过氧化反应的风险触发炎症反应导致心血管疾病(CVD)和动脉粥样硬化。作为一个安全的和容忍的附属物他汀类药物来控制hyperlipidaemia更多比他汀类药物。

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