Photobiomodulation therapy and vitamin C on longevity of cell sheets of human dental pulp stem cells

Pedroni Ana C.F.; Diniz Ivana M.A.; Abe Gabriela L.Moreira Maria S.Sipert Carla R.Marques Márcia M.

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Photobiomodulation therapy and vitamin C on longevity of cell sheets of human dental pulp stem cells

机译：Photobiomodulation疗法和维生素C长寿的细胞人类牙髓的床单干细胞

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Photobiomodulation therapy (PBMT) can improve processes relevant to tissue regeneration, such as survival, proliferation, migration, and differentiation of cells, including stem cells. Thus, PBMT could be applied as auxiliary therapy for tissue regeneration. Cell sheets (CSs) induced by vitamin C (VC) can generate large amount of cells, which would also be useful for tissue regeneration. VC and PBMT cause opposite effects on cell metabolism (e.g., VC is antioxidative, and PBMT generates reactive oxygen species); however, hDPSC CSs were formed when VC and PBMT+VC were applied. Thus, this study showed that PBMT does not interfere with the formation of cell sheets induced by VC. Additionally, PBMT improved the functional differentiation of the cells isolated from the CSs. Thus, due to the clinical benefits of PBMT, the association of this therapy with cell sheets seems promising for future applications in tissue regeneration.

机译：Photobiomodulation疗法(PBMT)可以改善流程与组织再生等生存、增殖、迁移和分化的细胞,包括干细胞。因此,PBMT可以应用作为辅助治疗组织再生。引起维生素C (VC)可以生成大数量的细胞,这也是有用的组织再生。对细胞代谢的影响(例如,VC抗氧化,PBMT产生活性氧物种);和PBMT + VC应用。PBMT不干扰的形成的细胞表由VC。改善的功能分化细胞分离的CSs。临床PBMT的好处,协会这与细胞表似乎有前途的治疗未来的应用在组织再生。

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来源
《Journal of Cellular Physiology》 |2018年第10期|7026-7035|共10页
作者
Pedroni Ana C.F.; Diniz Ivana M.A.; Abe Gabriela L.Moreira Maria S.Sipert Carla R.Marques Márcia M.;
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作者单位

Department of Restorative Dentistry, School of DentistryUniversity of Sao PauloSao Paulo,Brazil;

Post Graduation Program of the School of DentistryIbirapuera UniversitySao Paulo,Brazil;

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正文语种英语
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关键词
Low-Level Light Therapy; Ascorbic Acid; dental pulp stem celltissue repairtissue regenerationcellular metabolismStem CellsCell DifferentiationLongevity;

机译：低光照疗法;抗坏血酸;牙髓茎celltissue repairtissue regenerationcellularmetabolismStem CellsCell DifferentiationLongevity;

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Photobiomodulation therapy and vitamin C on longevity of cell sheets of human dental pulp stem cells

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