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首页> 外文期刊>Journal of Cellular Physiology >Low NR3C2 levels correlate with aggressive features and poor prognosis in non‐distant metastatic clear‐cell renal cell carcinoma
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Low NR3C2 levels correlate with aggressive features and poor prognosis in non‐distant metastatic clear‐cell renal cell carcinoma

机译：NR3C2水平低与咄咄逼人特性和不良预后不遥远转移性明显细胞肾细胞癌

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摘要

NR3C2 has previously been described as a tumor suppressor gene in several cancers; however the prognostic significance and biological function of NR3C2 in patients with non‐metastatic clear cell renal cell carcinoma (ccRCC) remain largely unclear. The prognostic value of NR3C2 expression was evaluated using data from The Cancer Genome Atlas (TCGA) and 181 patients with non‐metastatic ccRCC undergoing nephrectomy in our center. Predictive nomograms were generated and identified independent prognosticators to assess ccRCC patient overall survival (OS) and progression free survival (PFS) at 1, 5, and 8 years. The functional involvement of NR3C2 in RCC was examined in both in vitro and in vivo models upon overexpression of NR3C2. NR3C2 was found to be downregulated in tumor tissues and was correlated with several clinicopathological parameters, including the T status ( p ?0.001) and histological Fuhrman grade ( p ?=?0.002). Both Cox regression analysis and Kaplan‐Meier survival curves showed that low NR3C2 expression correlated with poor OS (HR?=?2.21, p ?=?0.014) and PFS (HR?=?1.71, p ?=?0.051). The incorporation of NR3C2 status into the T stage, UISS, or SSIGN scores helps to refine individual risk stratification. The newly built nomograms involving NR3C2 expression could better predict OS and PFS. Overexpression of NR3C2 inhibited RCC cell proliferation, colony formation, invasion, migration, and vasculogenic mimicry in vitro and reduced the growth of RCC xenografts in vivo. Together, these results suggest that NR3C2 may serve as a potential prognostic factor in non‐metastatic ccRCC patients after nephrectomy and is involved in RCC oncogenesis.
机译：NR3C2曾被描述为一个肿瘤在一些癌症抑制基因;和生物功能预后意义患者NR3C2非转移性明显细胞肾细胞癌(ccRCC)仍然很大程度上不清楚。评估使用癌症基因组的数据(TCGA)和181例非转移性在我们中心ccRCC接受肾切除术。预测计算图表生成评估确定独立的预后因子ccRCC患者总生存期(OS)无进展生存(PFS) 1、5、8年。是研究在体外和体内模型NR3C2超表达。在肿瘤组织和表达下调与几个相关临床病理的参数,包括T状态(p& 0.001)和组织学Fuhrman品位(p? = 0.002)。卡普兰Meier生存曲线表明,低NR3C2表达式与贫穷相关的操作系统(HR ? = 2.21, p = ? 0.014)和PFS (HR ? = 1.71, p? = 0.051)。T阶段,ui或SSIGN评分有助于完善个人危险分层。建立诺模图涉及NR3C2表达式更好地预测操作系统和PFS。NR3C2抑制细胞增殖,碾压混凝土的殖民地形成、入侵、迁移和vasculogenic模仿体外,减少碾压混凝土的发展异种移植体内。表明NR3C2可能作为一个潜在的非转移性ccRCC应承担的预后因素肾切除术后患者,碾压混凝土肿瘤形成。

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