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首页> 外文期刊>Journal of Cellular Physiology >Beyond voltage‐gated ion channels: Voltage‐operated membrane proteins and cellular processes
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Beyond voltage‐gated ion channels: Voltage‐operated membrane proteins and cellular processes

机译：除了电压量的离子通道:电压检测膜蛋白和细胞操作流程

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摘要

Voltage‐gated ion channels were believed to be the only voltage‐sensitive proteins in excitable (and some non‐excitable) cells for a long time. Emerging evidence indicates that the voltage‐operated model is shared by some other transmembrane proteins expressed in both excitable and non‐excitable cells. In this review, we summarize current knowledge about voltage‐operated proteins, which are not classic voltage‐gated ion channels as well as the voltage‐dependent processes in cells for which single voltage‐sensitive proteins have yet to be identified. Particularly, we will focus on the following. (1) Voltage‐sensitive phosphoinositide phosphatases (VSP) with four transmembrane segments homologous to the voltage sensor domain (VSD) of voltage‐gated ion channels; VSPs are the first family of proteins, other than the voltage‐gated ion channels, for which there is sufficient evidence for the existence of the VSD domain; (2) Voltage‐gated proton channels comprising of a single voltage‐sensing domain and lacking an identified pore domain; (3) G protein coupled receptors (GPCRs) that mediate the depolarization‐evoked potentiation of Ca 2+ mobilization; (4) Plasma membrane (PM) depolarization‐induced but Ca 2+ ‐independent exocytosis in neurons. (5) Voltage‐dependent metabolism of phosphatidylinositol 4,5‐bisphosphate (PtdIns[4,5]P 2 , PIP 2 ) in the PM. These recent discoveries expand our understanding of voltage‐operated processes within cellular membranes.
机译：电压门控离子通道被认为是只有电压敏感的蛋白质在兴奋一些非兴奋)细胞很长一段时间。新兴证据表明电压检测操作模型由一些其他共享跨膜蛋白表达兴奋性和非兴奋性细胞。审查中,我们总结当前的知识电压检测的蛋白质,不经典电压检测的离子通道以及在细胞的电压量相关的流程单电压敏感蛋白质尚未识别。追随者。磷酸酶(VSP)有四个跨膜部分同源的电压传感器领域(VSD)电压量的离子通道;第一家庭的蛋白质,其他比电压检测的离子通道,有足够的证据存在的缺损域;组成一个电压传感领域和缺乏一个确定孔隙域;耦合的受体(GPCRs)调解去极化的诱发电位化Ca 2 +动员;去极化检测诱导但Ca 2 +独立在神经元胞外分泌。磷脂酰肌醇代谢4、5列车酮糖(PtdIns(4、5)P 2, PIP 2)点。电压检测操作过程的理解在细胞膜内。

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